Chemical Property of 2-Fluoroadenine
Chemical Property:
- Appearance/Colour:white to light yellow crystal powder
- Vapor Pressure:0.00234mmHg at 25°C
- Melting Point:>350 °C(lit.)
- Refractive Index:1.894
- Boiling Point:676.9 °C at 760 mmHg
- PKA:6.84±0.20(Predicted)
- Flash Point:363.2 °C
- PSA：80.48000
- Density:1.739 g/cm3
- LogP:0.65540
- Storage Temp.:Refrigerator
- Solubility.:DMSO (Sparingly, Sonicated, Heated), Methanol (Slightly, Heated)
- XLogP3:-0.1
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:0
- Exact Mass:153.04507331
- Heavy Atom Count:11
- Complexity:154
- Purity/Quality:
-
99% *data from raw suppliers
2-Fluoroadenine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi,Xn
- Statements:
36/37/38-22
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=NC2=NC(=NC(=C2N1)N)F
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Description
2-Fluoroadenine is a purine nucleoside analog which has been investigated for suicide gene therapy for human malignancy. It has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro. It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 μM.
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Uses
A purine nucleoside phosphorylase gene therapy for human malignancy. 2-Fluoroadenine is a fluorinated heterocyclic 2-ring compound. It is the base moiety for many carbocyclic and acyclic nucleoside analogues, which may be used in antineoplastic studies. 2-Fluoroadenine has been used as an intermediate for antineoplastic drugs such as fludarabine. fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia.
