(1R,4aR,8aR)-1-(2-Methoxy-6-methoxymethoxy-benzyl)-8a-methyl-decahydro-naphthalene

Base Information

Chemical Name:(1R,4aR,8aR)-1-(2-Methoxy-6-methoxymethoxy-benzyl)-8a-methyl-decahydro-naphthalene
CAS No.:180912-53-2
Molecular Formula:C₂₁H₃₂O₃
Molecular Weight:332.483
Hs Code.:

Synonyms:(1R,4aR,8aR)-1-(2-Methoxy-6-methoxymethoxy-benzyl)-8a-methyl-decahydro-naphthalene

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Chemical Property of (1R,4aR,8aR)-1-(2-Methoxy-6-methoxymethoxy-benzyl)-8a-methyl-decahydro-naphthalene

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Technology Process of (1R,4aR,8aR)-1-(2-Methoxy-6-methoxymethoxy-benzyl)-8a-methyl-decahydro-naphthalene

There total 11 articles about (1R,4aR,8aR)-1-(2-Methoxy-6-methoxymethoxy-benzyl)-8a-methyl-decahydro-naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 185394-26-7
(2-Methoxy-6-methoxymethoxy-phenyl)-((1S,4aR,8aR)-8a-methyl-decahydro-naphthalen-1-yl)-methanol

: 180912-53-2
(1R,4aR,8aR)-1-(2-Methoxy-6-methoxymethoxy-benzyl)-8a-methyl-decahydro-naphthalene

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;
DOI:10.1016/0040-4039(96)01209-9

Reference yield:

: 57234-28-3
1-methoxy-3-(methoxymethoxy)benzene

: 180912-53-2
(1R,4aR,8aR)-1-(2-Methoxy-6-methoxymethoxy-benzyl)-8a-methyl-decahydro-naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: t-BuLi / hexane / 0 °C

2: 81 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

With hydrogen; tert.-butyl lithium; palladium on activated charcoal; In methanol; hexane;
DOI:10.1016/0040-4039(96)01209-9

Reference yield:

: 100348-93-4
(R)-Wieland-Miescher ketone

: 180912-53-2
(1R,4aR,8aR)-1-(2-Methoxy-6-methoxymethoxy-benzyl)-8a-methyl-decahydro-naphthalene

Guidance literature:: Multi-step reaction with 10 steps

1: 77 percent / p-TsOH / benzene / Heating

2: 86 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

3: 63 percent / H₂NNH₂*H₂O, KOH / bis-(2-hydroxy-ethyl) ether / 200 °C

4: 90 percent / 4M HCl / ethanol / Ambient temperature

5: 87 percent / Zn, TiCl₄ / tetrahydrofuran / Ambient temperature

6: BH₃*THF / tetrahydrofuran / Ambient temperature

7: 3M NaOH, 30percent H₂O₂ / Ambient temperature

8: Dess-Martin periodinane / CH₂Cl₂ / Ambient temperature

9: 74 percent / t-BuLi / hexane / 0 °C

10: 81 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydroxide; borane-THF; hydrogen; dihydrogen peroxide; tert.-butyl lithium; titanium tetrachloride; Dess-Martin periodane; toluene-4-sulfonic acid; hydrazine hydrate; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; diethylene glycol; benzene;
DOI:10.1016/0040-4039(96)01209-9