2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

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Chemical Name:2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide
CAS No.:413620-79-8
Molecular Formula:C₅₆H₄₂F₆N₂O₁₀
Molecular Weight:1016.95
Hs Code.:

2,2,2-trifluoro-<i>N</i>-methyl-<i>N</i>-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

Synonyms:2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

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Chemical Property of 2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

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Technology Process of 2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

There total 9 articles about 2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 4885-02-3
Dichloromethyl methyl ether

: 358673-16-2
2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

: 413620-79-8
2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

Guidance literature:: With titanium tetrachloride; In dichloromethane;
DOI:10.1016/S0040-4020(01)01075-4

Reference yield:

: 550372-00-4
C₄₈H₄₄N₂O₄

: 413620-79-8
2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / tetrahydrofuran

2: 91 percent / TiCl₄ / CH₂Cl₂

With titanium tetrachloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)01075-4

Reference yield:

: 582-33-2
3-aminobenzoic acid ethyl ester

: 413620-79-8
2,2,2-trifluoro-N-methyl-N-(3-{1,1,6,6-tetrakis-(3-formyl-4-methoxy-phenyl)-6-[3-(methyl-trifluoroacetyl-amino)-phenyl]-hexa-2,4-diynyl}-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 100 percent / DMAP / pyridine / 18 h / 75 °C

2.1: 75 percent / NaOH / ethanol / 22 h / 60 °C

3.1: 94 percent / n-BuLi / hexane; tetrahydrofuran / -78 - 0 °C

4.1: AcCl / 2 h / 20 °C

4.2: 85 percent / benzene; tetrahydrofuran / 1.5 h / 20 °C

5.1: 74 percent / CuCl; N-methylpyrrolidine; O₂ / CH₂Cl₂ / 2.5 h / 20 °C

6.1: 100 percent / Mg / CH₂Cl₂; methanol / 24 h / 20 °C

7.1: 98 percent / tetrahydrofuran / 0 - 20 °C

8.1: 91 percent / TiCl₄ / CH₂Cl₂ / 0.75 h / 0 - 20 °C

With 1-Methylpyrrolidine; dmap; sodium hydroxide; n-butyllithium; oxygen; titanium tetrachloride; magnesium; acetyl chloride; copper(l) chloride; In tetrahydrofuran; pyridine; methanol; ethanol; hexane; dichloromethane; 4.2: Grignard reaction / 5.1: Glaser coupling;
DOI:10.1021/jo001775t