2,2-dimethylpropionic acid 2,3-dihydrofuran-2-ylmethyl ester

Base Information

• Chemical Name: 2,2-dimethylpropionic acid 2,3-dihydrofuran-2-ylmethyl ester
• CAS No.: 144867-90-3
• Molecular Formula: C₁₀H₁₆O₃
• Molecular Weight: 184.235
• Mol file: 144867-90-3.mol

Synonyms:2,2-dimethylpropionic acid 2,3-dihydrofuran-2-ylmethyl ester

Chemical Property of 2,2-dimethylpropionic acid 2,3-dihydrofuran-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2,2-dimethylpropionic acid 2,3-dihydrofuran-2-ylmethyl ester

There total 1 articles about 2,2-dimethylpropionic acid 2,3-dihydrofuran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran (32780-06-6) → 2,2-dimethylpropionic acid 2,3-dihydrofuran-2-ylmethyl ester (144867-90-3)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 4 h / 50 °C

2: DIBAL-H / tetrahydrofuran / 2 h / -78 °C

3: thionyl chloride / CH₂Cl₂ / 2 h / 23 °C

4: potassium t-butoxide / tetrahydrofuran / 1 h / -78 °C

With pyridine; thionyl chloride; potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4039(92)89018-8

Reference yield: 20.0%

2,2-dimethylpropionic acid 2,3-dihydrofuran-2-ylmethyl ester (144867-90-3) + N-Benzoyl-N,9-bis(trimethylsilyl)adenin (18055-47-5) → 2,2-Dimethyl-propionic acid (2S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-iodo-tetrahydro-furan-2-ylmethyl ester (144867-93-6)

Guidance literature:

With N-iodo-succinimide; In tetrahydrofuran; at -15 ℃;

DOI:10.1016/0040-4039(92)89018-8

Reference yield:

2,2-dimethylpropionic acid 2,3-dihydrofuran-2-ylmethyl ester (144867-90-3) → 2',3'-Dideoxyadenosine (4097-22-7)

Guidance literature:

Multi-step reaction with 4 steps

1: N-iodosuccinimide / 1 h / -20 °C

2: SnCl₄ / 1,2-dichloro-ethane / -20 deg C -> 23 deg C

3: H₂ / 10 percent Pd/C / ethanol / 3 h

4: CH₃ONa / methanol / 5 h / 23 °C

With N-iodo-succinimide; hydrogen; sodium methylate; tin(IV) chloride; palladium on activated charcoal; In methanol; ethanol; 1,2-dichloro-ethane;

DOI:10.1016/0040-4039(92)89018-8

upstream raw materials:

(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

Downstream raw materials:

2,2-Dimethyl-propionic acid (2S,4R,5R)-5-(6-benzoylamino-purin-9-yl)-4-iodo-tetrahydro-furan-2-ylmethyl ester

cordycepin

N-(9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

stavudin