2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(piperidin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

Base Information

Chemical Name:2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(piperidin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine
CAS No.:1399035-88-1
Molecular Formula:C₁₉H₂₄F₄N₄
Molecular Weight:384.42
Hs Code.:

Synonyms:2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(piperidin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

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Chemical Property of 2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(piperidin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

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Technology Process of 2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(piperidin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

There total 7 articles about 2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(piperidin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1399035-85-8
2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridine-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

: 1399035-88-1
2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(piperidin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

Guidance literature:: With hydrogenchloride; platinum(IV) oxide; hydrogen; In ethanol; water; at 70 ℃; for 24h; under 7240.26 Torr;
DOI:10.1055/s-0031-1290371

Reference yield:

: 1082951-17-4
(2-amino-1-(4-fluoro, 3-trifluoromethyl-phenyl)-ethanone) p-toluenesulfonate

: 1399035-88-1
2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(piperidin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.5 h / 25 °C

2.1: acetic acid / 20 h / 140 °C

3.1: potassium hydroxide / tetrahydrofuran / 1 h / 30 - 40 °C

3.2: 20 h / 60 - 65 °C

4.1: hydrogenchloride; platinum(IV) oxide; hydrogen / ethanol; water / 24 h / 70 °C / 7240.26 Torr

With hydrogenchloride; platinum(IV) oxide; hydrogen; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid;
DOI:10.1055/s-0031-1290371

Reference yield:

: 1399383-53-9
N-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}isonicotinamide

: 1399035-88-1
2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(piperidin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethyl acetate / 3 h / 5 - 15 °C

2.1: acetic acid / 20 h / 140 °C

3.1: potassium hydroxide / tetrahydrofuran / 1 h / 30 - 40 °C

3.2: 20 h / 60 - 65 °C

4.1: hydrogenchloride; platinum(IV) oxide; hydrogen / ethanol; water / 24 h / 70 °C / 7240.26 Torr

With hydrogenchloride; platinum(IV) oxide; hydrogen; potassium hydroxide; In tetrahydrofuran; ethanol; water; acetic acid; ethyl acetate;
DOI:10.1055/s-0031-1290371