1399383-53-9

Upstream product

• 55-22-1 pyridine-4-carboxylic acid 
• 1082951-17-4 (2-amino-1-(4-fluoro, 3-trifluoromethyl-phenyl)-ethanone) p-toluenesulfonate 

Downstream Products

• 1226950-80-6 2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine 
• 1226950-76-0 C₁₉H₂₅F₃N₄ 
• 1399035-80-3 N-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}isonicotinamide hydrochloride 
• 1399035-82-5 4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine acetic acid salt 
• 1399035-84-7 2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine 
• 1399035-85-8 2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridine-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine 
• 1399035-88-1 2-{5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(piperidin-4-yl)-1H-imidazol-1-yl}-N,N-dimethylethanamine 

Relevant academic research and scientific papers

A practical synthesis of 2-{4-[4-Fluoro-3-(trifluoromethyl)phenyl]-2- (piperidin-4-yl)-1H-imidazol-1-yl}- N, N -dimethylethanamine

A practical synthesis of the title compound was accomplished by hydrogenation of 2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1H- imidazol-1-yl}-N,N-dimethylethanamine. The latter was obtained by N-alkylation of 4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine. Treatment of N-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl} isonicotinamide hydrochloride with ammonium acetate in acetic acid provided 4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine. Coupling of 2-amino-1-[4-fluoro-3-(trifluoromethyl)phenyl]ethanone 4-methylbenzene sulfonate with pyridine 4-carboxylic acid using either T3P or EDCI-HOBt provided N-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl} isonicotinamide hydrochloride. Georg Thieme Verlag Stuttgart New York.