2-<6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxooctyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Base Information

Chemical Name:2-<6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxooctyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline
CAS No.:167159-51-5
Molecular Formula:C₂₇H₃₇NO₆
Molecular Weight:471.594
Hs Code.:

Synonyms:2-<6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxooctyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

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Chemical Property of 2-<6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxooctyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

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Technology Process of 2-<6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxooctyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

There total 6 articles about 2-<6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxooctyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 925-90-6
ethylmagnesium bromide

: 167159-66-2
2-<6-(3,4-dimethoxyphenyl)-1,6-dioxohexyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

: 167159-51-5
2-<6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxooctyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Guidance literature:: In tetrahydrofuran; at 25 ℃; for 12h;
DOI:10.1021/jm9804477

Reference yield:

: 1071-71-2
ethyl 6-chloro-6-oxohexanoate

: 167159-51-5
2-<6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxooctyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / AlCl₃ / CH₂Cl₂ / 16 h / 0 - 25 °C

2: 97 percent / 10 percent ethanolic NaOH / 3 h / 25 °C

3: 1.) Et₃N, 2.) diethyl cyanophosphate / 1.) DMF, 25 deg C, 12 h, 2.) DMF, 25 deg C, 12 h

4: 94 percent / tetrahydrofuran / 12 h / 25 °C

With sodium hydroxide; aluminium trichloride; diethyl cyanophosphonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm9804477

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 167159-51-5
2-<6-(3,4-dimethoxyphenyl)-6-hydroxy-1-oxooctyl>-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / AlCl₃ / CH₂Cl₂ / 16 h / 0 - 25 °C

2: 97 percent / 10 percent ethanolic NaOH / 3 h / 25 °C

3: 1.) Et₃N, 2.) diethyl cyanophosphate / 1.) DMF, 25 deg C, 12 h, 2.) DMF, 25 deg C, 12 h

4: 94 percent / tetrahydrofuran / 12 h / 25 °C

With sodium hydroxide; aluminium trichloride; diethyl cyanophosphonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm9804477