Praeruptorin A

Base Information

Chemical Name:Praeruptorin A
CAS No.:73069-25-7
Molecular Formula:C₂₁H₂₂O₇
Molecular Weight:386.401
Hs Code.:29329990
Mol file:73069-25-7.mol

Synonyms:(-)-pareruptorin A;

Suppliers and Price of Praeruptorin A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Praeruptorin A
20mg
$ 490.00

TRC
PraeruptorinA
100mg
$ 155.00

Medical Isotopes, Inc.
PraeruptorinA
100 mg
$ 625.00

Medical Isotopes, Inc.
PraeruptorinA
1 g
$ 2000.00

JR MediChem
Praeruptorin?A 98%
20mg
$ 136.00

JR MediChem
Praeruptorin?A 98%
5mg
$ 98.00

Crysdot
(±)-PraeruptorinA 97%
10mg
$ 80.00

Crysdot
(±)-PraeruptorinA 97%
25mg
$ 145.00

Crysdot
(±)-PraeruptorinA 97%
100mg
$ 420.00

Crysdot
(±)-PraeruptorinA 97%
50mg
$ 250.00

Total 56 raw suppliers

Chemical Property of Praeruptorin A

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.574
Boiling Point:486.817 °C at 760 mmHg
Flash Point:211.534 °C
PSA：92.04000
Density:1.289 g/cm³
LogP:3.44620
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Praeruptorin A ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Uses Praeruptorin A is used in the treatment of cardiac diseases, extracted from Peucedani Radix, it exhibits anti-hypertensive effects. Also a potential anti-tumor agent due to the ability to modulate P-glycoprotein (Pgp), overexpression in MDR tumor cells.

Technology Process of Praeruptorin A

There total 9 articles about Praeruptorin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.8%

: 35660-94-7
(E)-2-methylbut-2-enoyl chloride

: 4955-21-9,35345-45-0,107080-28-4,112346-42-6,118492-19-6,118492-23-2
(+/-)-trans-4'-acetylkhellactone

: 14017-71-1,73069-25-7,73069-27-9,81740-05-8,112346-41-5,118492-20-9,118492-26-5,127643-75-8
(+/-)-trans-4'-acetyl=3'-tigloylkhellactone

Guidance literature:: In benzene; Heating;
DOI:10.1248/cpb.43.859

Reference yield: 21.1%

: 35660-94-7,49651-33-4,62529-65-1
(Z)-2-methyl-2-butenoyl chloride

: 4955-21-9,35345-45-0,107080-28-4,112346-42-6,118492-19-6,118492-23-2
(+/-)-cis-4'-acetylkhellactone

: 14017-71-1,73069-25-7,73069-27-9,81740-05-8,112346-41-5,118492-20-9,118492-26-5,127643-75-8
(+/-)-4'-O-acetyl-3'-O-angeloyl-cis-khellactone

Guidance literature:: In benzene;
DOI:10.1248/cpb.36.4221

Reference yield:

: 523-59-1
seseline

: 14017-71-1,73069-25-7,73069-27-9,81740-05-8,112346-41-5,118492-20-9,118492-26-5,127643-75-8
(+/-)-cis-4'-acetyl-3'-tigloylkhellactone

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent Turnov_. / OsO₄, N-methylmorpholine-N-oxide dihydrate / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 72 h / Ambient temperature

2: 65 percent Turnov_. / BF₃*Et₂O / tetrahydrofuran / 2.8 h / Ambient temperature

3: 86 percent Turnov_. / 4-pyrrolidinopyridine, 1,3-dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 125 h / Heating

With osmium(VIII) oxide; boron trifluoride diethyl etherate; 4-pyrrolidin-1-ylpyridine; 4-methylmorpholine N-oxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.3987/R-1987-05-1239