3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoic acid

Base Information

Chemical Name:3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoic acid
CAS No.:1445786-66-2
Molecular Formula:C₃₀H₃₁N₅O₆
Molecular Weight:557.606
Hs Code.:

Synonyms:3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoic acid

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Chemical Property of 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoic acid

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Technology Process of 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoic acid

There total 6 articles about 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.6%

: 1445789-26-3
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate

: 1445786-66-2
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃;

Reference yield:

: 2550-36-9
Cyclohexylmethyl bromide

: 1445786-66-2
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation

2.1: hydrogen; acetic acid; palladium 10% on activated carbon / 20 °C

2.2: 20 °C

3.1: sodium hydroxide; water / methanol / 20 °C

With palladium 10% on activated carbon; water; hydrogen; potassium carbonate; acetic acid; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1374867-81-8
7-bromo-4-chloroquinoline-3-carboxamide

: 1445786-66-2
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

2.1: hydrogen; acetic acid; palladium 10% on activated carbon / 20 °C

2.2: 20 °C

3.1: sodium hydroxide; water / methanol / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; acetic acid; sodium hydroxide; In 1,4-dioxane; methanol; water;