methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate

Base Information

Chemical Name:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate
CAS No.:1445789-26-3
Molecular Formula:C₃₁H₃₃N₅O₆
Molecular Weight:571.633
Hs Code.:

Synonyms:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate

Suppliers and Price of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate

There total 5 articles about methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.1%

: 1445789-24-1
methyl 3-[(cyclohexylmethyl)oxy]-5-nitrobenzoate

: 1374867-83-0
4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

: 1445789-26-3
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate

Guidance literature:: methyl 3-[(cyclohexylmethyl)oxy]-5-nitrobenzoate; With palladium 10% on activated carbon; hydrogen; acetic acid; at 20 ℃;

4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide; at 20 ℃;

Reference yield:

: 2550-36-9
Cyclohexylmethyl bromide

: 1445789-26-3
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation

2.1: hydrogen; acetic acid; palladium 10% on activated carbon / 20 °C

2.2: 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

Reference yield:

: 1374867-81-8
7-bromo-4-chloroquinoline-3-carboxamide

: 1445789-26-3
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexylmethoxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

2.1: hydrogen; acetic acid; palladium 10% on activated carbon / 20 °C

2.2: 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In 1,4-dioxane; water;