4-fluorobenzyl(4-methylphenyl)sulfane

Base Information

• Chemical Name: 4-fluorobenzyl(4-methylphenyl)sulfane
• CAS No.: 1494-33-3
• Molecular Formula: C₁₄H₁₃FS
• Molecular Weight: 232.322
• Mol file: 1494-33-3.mol

Synonyms:4-fluorobenzyl(4-methylphenyl)sulfane

Chemical Property of 4-fluorobenzyl(4-methylphenyl)sulfane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-fluorobenzyl(4-methylphenyl)sulfane

There total 12 articles about 4-fluorobenzyl(4-methylphenyl)sulfane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-fluorobenzylic alcohol (459-56-3) + para-thiocresol (106-45-6) → 4-fluorobenzyl(4-methylphenyl)sulfane (1494-33-3)

Guidance literature:

With 4-Fluorobenzyl bromide; In neat (no solvent); at 120 ℃; for 12h; Schlenk technique; Sealed tube;

DOI:10.1039/c7ob02461d

Reference yield: 92.0%

4-tolyl iodide (624-31-7) + (4-fluorophenyl)methanethiol (15894-04-9) → 4-fluorobenzyl(4-methylphenyl)sulfane (1494-33-3)

Guidance literature:

With pyridine; (1,2-dimethoxyethane)dichloronickel(II); Ir[dF(CF₃)ppy]2(dtbbpy)PF₆; 4,4′-di-(tert-butyl)-2,2′-bipyridyl; In acetonitrile; at 23 - 25 ℃; for 24h; chemoselective reaction; Irradiation;

DOI:10.1021/jacs.5b11244

Reference yield: 87.0%

p-fluorobenzyltrimethylammonium bromide (333-45-9) + para-thiocresol (106-45-6) → 4-fluorobenzyl(4-methylphenyl)sulfane (1494-33-3)

Guidance literature:

With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; potassium tert-butylate; In acetonitrile; at 70 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.jorganchem.2021.122176

upstream raw materials:

para-thiocresol

1-chloromethyl-4-fluorobenzene

4-Fluorobenzyl bromide

sodium p-thiocresolate

Downstream raw materials:

1-fluoro-4-((p-tolylsulfinyl)methyl)benzene

1-fluoro-4-(4-tolylsulfonylmethyl)benzene

C₂₀H₂₄BrFS

(E)-methyl 3-(5-fluoro-2-(p-tolylsulfinylmethyl)phenyl)acrylate