2-methoxy-4-(3-oxopropyl)phenyl ethanoate

Base Information

• Chemical Name: 2-methoxy-4-(3-oxopropyl)phenyl ethanoate
• CAS No.: 1006614-61-4
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 1006614-61-4.mol

Synonyms:2-methoxy-4-(3-oxopropyl)phenyl ethanoate

Chemical Property of 2-methoxy-4-(3-oxopropyl)phenyl ethanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-4-(3-oxopropyl)phenyl ethanoate

There total 4 articles about 2-methoxy-4-(3-oxopropyl)phenyl ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

(E)-2-methoxy-4-(3-oxoprop-1-en-1-yl)phenyl acetate (65401-83-4,83071-67-4) → 2-methoxy-4-(3-oxopropyl)phenyl ethanoate (1006614-61-4)

Guidance literature:

With sodium hydrogencarbonate; rac-nornicotine; In phosphate buffer; dimethyl sulfoxide; at 32 ℃; for 7h; pH=7.0;

DOI:10.1039/b713273e

Reference yield:

4-acetoxy-3-methoxycinnamaldehyde (65401-83-4) → 2-methoxy-4-(3-oxopropyl)phenyl ethanoate (1006614-61-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2017.10.063

Reference yield:

carbon monoxide (201230-82-2) + 4-acetoxy-3-methoxyvinylbenzene (46316-15-8) → 2-methoxy-4-(3-oxopropyl)phenyl ethanoate (1006614-61-4) + C12H14O4

Guidance literature:

With methoxy(cyclooctadiene)rhodium(I) dimer; tris(2,4-di-tert-butylphenyl)phosphite; hydrogen; In toluene; at 60 ℃; for 4h; under 30003 Torr; Schlenk technique; Glovebox;

DOI:10.1039/d1cy01801a

upstream raw materials:

(E)-2-methoxy-4-(3-oxoprop-1-en-1-yl)phenyl acetate

4-acetoxy-3-methoxycinnamaldehyde

2-methoxy-4-(prop-1-enyl)phenyl acetate

carbon monoxide

Downstream raw materials:

(E)-2-methoxy-4-(3-oxoprop-1-en-1-yl)phenyl acetate

Refernces

• 1、 Brogan, Andrew P.,Dickerson, Tobin J.,Janda, Kim D.. "Nornicotine-organocatalyzed aqueous reduction of α,β-unsaturated aldehydes". . p. 4952 - 4954. Retrieved 2007.