(R)-1-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Base Information

Chemical Name:(R)-1-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide
CAS No.:1159997-27-9
Molecular Formula:C₂₀H₁₈F₆N₂O
Molecular Weight:416.366
Hs Code.:

Synonyms:(R)-1-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

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Chemical Property of (R)-1-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

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Technology Process of (R)-1-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

There total 6 articles about (R)-1-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.2%

: 125278-10-6,779303-24-1
(S)-1,1,1-trifluoropropan-2-amine

: 1159997-92-8
(R)-(-)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

: 530-62-1
1,1'-carbonyldiimidazole

: 1159997-27-9
(R)-1-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Guidance literature:: In tetrahydrofuran; dichloromethane; at 20 ℃;
DOI:10.1021/jm401955h

Reference yield:

: 64-04-0
phenethylamine

: 1159997-27-9
(R)-1-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: phosphorus pentoxide / 165 °C

3: sodium tetrahydroborate / methanol / 20 °C

4: chiral column / Resolution of racemate

5: dichloromethane; tetrahydrofuran / 20 °C

With sodium tetrahydroborate; phosphorus pentoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; 2: |Bischler-Napieralski Reaction;
DOI:10.1021/jm401955h

Reference yield:

: 38925-76-7
N-phenethyl-4-(trifluoromethyl)benzamide

: 1159997-27-9
(R)-1-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus pentoxide / 165 °C

2: sodium tetrahydroborate / methanol / 20 °C

3: chiral column / Resolution of racemate

4: dichloromethane; tetrahydrofuran / 20 °C

With sodium tetrahydroborate; phosphorus pentoxide; In tetrahydrofuran; methanol; dichloromethane; 1: |Bischler-Napieralski Reaction;
DOI:10.1021/jm401955h