L-2,2,2-TRIFLUORO-1-(METHYL)ETHYLAMINE

Base Information

• Chemical Name: L-2,2,2-TRIFLUORO-1-(METHYL)ETHYLAMINE
• CAS No.: 125278-10-6
• Molecular Formula: C3H6F3N
• Molecular Weight: 113.083
• Hs Code.: 2921199990
• Mol file: 125278-10-6.mol

Synonyms:L-2,2,2-TRIFLUORO-1-(METHYL)ETHYLAMINE;(S)-1-Methyl-2,2,2-trifluoroethylamine;L-1-Methyl-2,2,2-trifluoroethylamine 98%;(S)-2-AMino-1,1,1-trifluoropropane;(S)-1,1,1-trifluoropropan-2-aMine;(S)-1,1,1-Trifluoroprop-2-ylamine

Chemical Property of L-2,2,2-TRIFLUORO-1-(METHYL)ETHYLAMINE

Chemical Property:

• Vapor Pressure: 205.136mmHg at 25°C
• Boiling Point: 58.9±35.0℃ (760 Torr)
• PKA: 5.82±0.50(Predicted)
• Flash Point: -1.7±10.6℃
• PSA: 26.02000
• Density: 1.148±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 1.59620

Purity/Quality:

98%Min ^*data from raw suppliers

(2S)-1,1,1-Trifluoropropan-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-2,2,2-TRIFLUORO-1-(METHYL)ETHYLAMINE

There total 4 articles about L-2,2,2-TRIFLUORO-1-(METHYL)ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-Trifluoro-1-methylethanamine (421-49-8,779303-24-1) + Isopropyl acetate (108-21-4) → (S)-1,1,1-trifluoropropan-2-amine (125278-10-6,779303-24-1) + (R)-N-(1,1,1-trifluoropropan-2-yl)acetamide (1589570-32-0)

Guidance literature:

With palladium/alumina; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 50 ℃; for 24h; stereoselective reaction; Molecular sieve; Resolution of racemate; Green chemistry; Enzymatic reaction;

DOI:10.1039/c3ra40526e

Reference yield:

2,2,2-Trifluoro-1-methylethanamine (421-49-8,779303-24-1) + Isopropyl acetate (108-21-4) → (S)-1,1,1-trifluoropropan-2-amine (125278-10-6,779303-24-1) + (R)-N-(1,1,1-trifluoropropan-2-yl)acetamide (1589570-32-0) + (S)-N-(1,1,1-trifluoropropan-2-yl)acetamide

Guidance literature:

With lipase immobilized on acrylic resin from Candida antarctica; In tetrahydrofuran; at 20 ℃; for 24h; Reagent/catalyst; Solvent; Temperature; Time; enantioselective reaction; Catalytic behavior; Molecular sieve; Resolution of racemate; Green chemistry; Enzymatic reaction;

DOI:10.1039/c3ra40526e

Reference yield:

C11H12F3N → (S)-1,1,1-trifluoropropan-2-amine (125278-10-6,779303-24-1)

Guidance literature:

C₁₁H₁₂F₃N; With hydrogenchloride; In tert-butyl methyl ether; water; at 20 ℃; for 13h;

With sodium hydroxide; In tert-butyl methyl ether; water; Reflux;

DOI:10.1016/j.bmcl.2013.04.049

upstream raw materials:

2,2,2-Trifluoro-1-methylethanamine

Isopropyl acetate

Downstream raw materials:

6-chloro-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-5-(2,4,6-trifluorophenyl)pyrimidin-4-amine

3-cyano-5-chloro-6-(2-chloro-4-fluorophenyl)-7-(S)-1',1',1-trifluoroprop-2-ylaminopyrazolo[1,5-a]pyrimidine

Refernces

• 1、 Cheng, Guilin,Xia, Bo,Wu, Qi,Lin, Xianfu. "Chemoenzymatic dynamic kinetic resolution of α-trifluoromethylated amines: Influence of substitutions on the reversed stereoselectivity". . p. 9820 - 9828. Retrieved 2013/09/02.