(2R,3S)-3-(benzyloxy)-2-(3-chloro-4-cyano-2-methylphenylamino)-4,4,4-trifluorobutanoic acid

Base Information

Chemical Name:(2R,3S)-3-(benzyloxy)-2-(3-chloro-4-cyano-2-methylphenylamino)-4,4,4-trifluorobutanoic acid
CAS No.:1252051-62-9
Molecular Formula:C₁₉H₁₆ClF₃N₂O₃
Molecular Weight:412.796
Hs Code.:

Synonyms:(2R,3S)-3-(benzyloxy)-2-(3-chloro-4-cyano-2-methylphenylamino)-4,4,4-trifluorobutanoic acid

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Chemical Property of (2R,3S)-3-(benzyloxy)-2-(3-chloro-4-cyano-2-methylphenylamino)-4,4,4-trifluorobutanoic acid

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Technology Process of (2R,3S)-3-(benzyloxy)-2-(3-chloro-4-cyano-2-methylphenylamino)-4,4,4-trifluorobutanoic acid

There total 4 articles about (2R,3S)-3-(benzyloxy)-2-(3-chloro-4-cyano-2-methylphenylamino)-4,4,4-trifluorobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 796600-15-2
2-chloro-4-fluoro-3-methylbenzonitrile

: 1252051-57-2
(2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid hydrochloride

: 1252051-62-9
(2R,3S)-3-(benzyloxy)-2-(3-chloro-4-cyano-2-methylphenylamino)-4,4,4-trifluorobutanoic acid

Guidance literature:: With caesium carbonate; In dimethyl sulfoxide; Heating;
DOI:10.1016/j.tetlet.2010.07.147

Reference yield:

: 1252051-54-9
tert-butyl (2S,3S)-3-(benzyloxy)-4,4,4-trifluoro-1-hydroxybutan-2-ylcarbamate

: 1252051-62-9
(2R,3S)-3-(benzyloxy)-2-(3-chloro-4-cyano-2-methylphenylamino)-4,4,4-trifluorobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Jones reagent / acetone / 3 h / 0 °C

2: hydrogenchloride / ethyl acetate / 1.5 h / 0 - 20 °C

3: caesium carbonate / dimethyl sulfoxide / 48 h / 20 - 80 °C

With hydrogenchloride; Jones reagent; caesium carbonate; In dimethyl sulfoxide; ethyl acetate; acetone;

Reference yield:

: 1252051-56-1
(2R,3S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-4,4,4-trifluorobutanoic acid

: 1252051-62-9
(2R,3S)-3-(benzyloxy)-2-(3-chloro-4-cyano-2-methylphenylamino)-4,4,4-trifluorobutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 1.5 h / 0 - 20 °C

2: caesium carbonate / dimethyl sulfoxide / 48 h / 20 - 80 °C

With hydrogenchloride; caesium carbonate; In dimethyl sulfoxide; ethyl acetate;