(2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid hydrochloride

Base Information

Chemical Name:(2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid hydrochloride
CAS No.:1252051-57-2
Molecular Formula:C₁₁H₁₂F₃NO₃*ClH
Molecular Weight:299.677
Hs Code.:

Synonyms:(2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid hydrochloride

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Chemical Property of (2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid hydrochloride

There total 3 articles about (2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1252051-56-1
(2R,3S)-3-(benzyloxy)-2-(tert-butoxycarbonylamino)-4,4,4-trifluorobutanoic acid

: 1252051-57-2
(2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃;
DOI:10.1016/j.tetlet.2010.07.147

Reference yield:

: 1252051-54-9
tert-butyl (2S,3S)-3-(benzyloxy)-4,4,4-trifluoro-1-hydroxybutan-2-ylcarbamate

: 1252051-57-2
(2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: Jones reagent / acetone / 3 h / 0 °C

2: hydrogenchloride / ethyl acetate / 1.5 h / 0 - 20 °C

With hydrogenchloride; Jones reagent; In ethyl acetate; acetone;

Reference yield:

: (S)-tert-butyl 4-(1-(benzyloxy)-2,2,2-trifluoroethyl)-2,2-dimethyloxazolidine-3-carboxylate

: 1252051-57-2
(2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / methanol / 120 h / 20 °C

2: Jones reagent / acetone / 3 h / 0 °C

3: hydrogenchloride / ethyl acetate / 1.5 h / 0 - 20 °C

With hydrogenchloride; Jones reagent; toluene-4-sulfonic acid; In methanol; ethyl acetate; acetone;