5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-phenethyl-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-phenethyl-1H-pyrazole-3-carboxamide
CAS No.:1265633-69-9
Molecular Formula:C₂₅H₂₀Cl₃N₃O
Molecular Weight:484.812
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-phenethyl-1H-pyrazole-3-carboxamide

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Chemical Property of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-phenethyl-1H-pyrazole-3-carboxamide

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Technology Process of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-phenethyl-1H-pyrazole-3-carboxamide

There total 3 articles about 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-phenethyl-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 64-04-0
phenethylamine

: 162758-35-2
rimonabant acid

: 1265633-69-9
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-phenethyl-1H-pyrazole-3-carboxamide

Guidance literature:: rimonabant acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

phenethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bioorg.2021.105302

Reference yield:

: 158941-22-1
ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate

: 1265633-69-9
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-phenethyl-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / methanol / 4 h / 60 °C

2.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 0.17 h / 20 °C

2.2: 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In methanol; dichloromethane;
DOI:10.1016/j.bioorg.2021.105302

Reference yield:

: 6285-05-8
4'-chloropropiophenone

: 1265633-69-9
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-phenethyl-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / 16 h / -78 - 20 °C

1.2: 20 h / 20 °C

1.3: 24 h / Reflux

2.1: potassium hydroxide / methanol / 4 h / 60 °C

3.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 0.17 h / 20 °C

3.2: 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; lithium hexamethyldisilazane; In methanol; dichloromethane;
DOI:10.1016/j.bioorg.2021.105302