3-(3-methoxyphenyl)-1-methyl-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridin-2-one

Base Information

• Chemical Name: 3-(3-methoxyphenyl)-1-methyl-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridin-2-one
• CAS No.: 310902-43-3
• Molecular Formula: C₁₈H₂₃NO₂
• Molecular Weight: 285.386

Synonyms:3-(3-methoxyphenyl)-1-methyl-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridin-2-one

Chemical Property of 3-(3-methoxyphenyl)-1-methyl-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of 3-(3-methoxyphenyl)-1-methyl-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridin-2-one

There total 4 articles about 3-(3-methoxyphenyl)-1-methyl-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-(3-methoxyphenyl)-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridine-2-one (310902-41-1) + methyl iodide (74-88-4) → 3-(3-methoxyphenyl)-1-methyl-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridin-2-one (310902-43-3)

Guidance literature:

3-(3-methoxyphenyl)-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridine-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1002/jhet.5570370422

Reference yield:

4-(1-cyclohepten-1-yl)morpholine (7182-08-3) → 3-(3-methoxyphenyl)-1-methyl-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridin-2-one (310902-43-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 83 percent / 20 h / 120 °C

2.1: 53 percent / HCONH₂ / 4 h / 170 °C

3.1: NaH / dimethylformamide / 1 h / 20 °C

3.2: 64 percent / dimethylformamide / 2 h / 20 °C

With sodium hydride; formamide; In N,N-dimethyl-formamide; 1.1: Condensation / 2.1: Substitution / 3.1: Metallation / 3.2: Methylation;

DOI:10.1002/jhet.5570370422

Reference yield:

methyl 3-dimethylamino-2-(3-methoxyphenyl)propanoate → 3-(3-methoxyphenyl)-1-methyl-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridin-2-one (310902-43-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 83 percent / 20 h / 120 °C

2.1: 53 percent / HCONH₂ / 4 h / 170 °C

3.1: NaH / dimethylformamide / 1 h / 20 °C

3.2: 64 percent / dimethylformamide / 2 h / 20 °C

With sodium hydride; formamide; In N,N-dimethyl-formamide; 1.1: Condensation / 2.1: Substitution / 3.1: Metallation / 3.2: Methylation;

DOI:10.1002/jhet.5570370422

upstream raw materials:

3-(3-methoxyphenyl)-1,3,4,5,6,7,8,9-octahydro-2H-cyclohepta[b]pyridine-2-one

methyl iodide

4-(1-cyclohepten-1-yl)morpholine

3-(3-methoxyphenyl)-4,5,6,7,8,9-hexahydrocyclohepta[b]pyran-2(3H)-one

Downstream raw materials:

3-(3-methoxyphenyl)-1-methyl-1,2,3,4,5,6,7,8,9-octahydro-1H-cyclohepta[b]pyridine

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