(2R,4S,5R)-1-(3-bromo-4-tert-butylbenzoyl)-2-(1H-pyrazol-1-yl-methyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester

Base Information

Chemical Name:(2R,4S,5R)-1-(3-bromo-4-tert-butylbenzoyl)-2-(1H-pyrazol-1-yl-methyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester
CAS No.:932400-12-9
Molecular Formula:C₂₉H₃₅BrN₄O₅S
Molecular Weight:631.591
Hs Code.:

(2R,4S,5R)-1-(3-bromo-4-tert-butylbenzoyl)-2-(1H-pyrazol-1-yl-methyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester

Synonyms:(2R,4S,5R)-1-(3-bromo-4-tert-butylbenzoyl)-2-(1H-pyrazol-1-yl-methyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester

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Chemical Property of (2R,4S,5R)-1-(3-bromo-4-tert-butylbenzoyl)-2-(1H-pyrazol-1-yl-methyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester

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Technology Process of (2R,4S,5R)-1-(3-bromo-4-tert-butylbenzoyl)-2-(1H-pyrazol-1-yl-methyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester

There total 1 articles about (2R,4S,5R)-1-(3-bromo-4-tert-butylbenzoyl)-2-(1H-pyrazol-1-yl-methyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: rel-(2R,4S,5R)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester

: 521955-78-2
3-bromo-4-tert-butylbenzoyl chloride

: 932400-12-9
(2R,4S,5R)-1-(3-bromo-4-tert-butylbenzoyl)-2-(1H-pyrazol-1-yl-methyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 932400-12-9
(2R,4S,5R)-1-(3-bromo-4-tert-butylbenzoyl)-2-(1H-pyrazol-1-yl-methyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester

: 932400-13-0
(2R,4S,5R)-1-(3-bromo-4-tert-butylbenzoyl)-4-(hydroxymethyl)-2-(1H-pyrazol-1-ylmethyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2-carboxylic acid, tert-butyl ester

Guidance literature:: (2R,4S,5R)-1-(3-bromo-4-tert-butylbenzoyl)-2-(1H-pyrazol-1-yl-methyl)-5-(1,3-thiazol-2-yl)pyrrolidine-2,4-dicarboxylic acid, 2-tert-butyl ester, 4-methyl ester; With lithium triethylborohydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.03333h;

With hydrogenchloride; In tetrahydrofuran; water;