(S)-5-oxo-1-(phenylmethyl)-2-pyrrolidineacetaldehyde

Base Information

Chemical Name:(S)-5-oxo-1-(phenylmethyl)-2-pyrrolidineacetaldehyde
CAS No.:131879-89-5
Molecular Formula:C₁₃H₁₅NO₂
Molecular Weight:217.268
Hs Code.:

Synonyms:(S)-5-oxo-1-(phenylmethyl)-2-pyrrolidineacetaldehyde

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Chemical Property of (S)-5-oxo-1-(phenylmethyl)-2-pyrrolidineacetaldehyde

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Technology Process of (S)-5-oxo-1-(phenylmethyl)-2-pyrrolidineacetaldehyde

There total 9 articles about (S)-5-oxo-1-(phenylmethyl)-2-pyrrolidineacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

: 132014-74-5
(S)-1-(phenylmethyl)-5-(2-propenyl)-2-pyrrolidinone

: 131879-89-5
(S)-5-oxo-1-(phenylmethyl)-2-pyrrolidineacetaldehyde

Guidance literature:: With dimethylsulfide; ozone; In methanol; dichloromethane; at -78 ℃; for 6.5h;
DOI:10.1021/jm00015a009

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 131879-89-5
(S)-5-oxo-1-(phenylmethyl)-2-pyrrolidineacetaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaBH₄, NaOH, 2.) 6N HCl / H₂O / 1.) from 10 to 15 deg C, 30 min, 2.) RT, overnight

2: 55 percent / aq. HCl / Heating

3: 132 g / conc. H₂SO₄ / toluene / Heating

4: 77 percent / NaBH₄, MeOH / 2-methyl-propan-2-ol / Ambient temperature

5: DMAP / CH₂Cl₂ / Ambient temperature

6: NaI / acetone / Heating

7: 66 percent / Li₂CuCl₄ / tetrahydrofuran / -78 °C

8: 84.4 percent / 1.) O₃, 2.) aq. Me₂S / methanol; CH₂Cl₂ / 6.5 h / -78 °C

With hydrogenchloride; methanol; dmap; sodium hydroxide; sodium tetrahydroborate; dilithium tetrachlorocuprate; dimethylsulfide; sulfuric acid; ozone; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene; tert-butyl alcohol;
DOI:10.1021/jm00015a009

Reference yield:

: 77539-18-5,73914-82-6
(S)-(+)-2-benzylamino glutaric acid

: 131879-89-5
(S)-5-oxo-1-(phenylmethyl)-2-pyrrolidineacetaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: 55 percent / aq. HCl / Heating

2: 132 g / conc. H₂SO₄ / toluene / Heating

3: 77 percent / NaBH₄, MeOH / 2-methyl-propan-2-ol / Ambient temperature

4: DMAP / CH₂Cl₂ / Ambient temperature

5: NaI / acetone / Heating

6: 66 percent / Li₂CuCl₄ / tetrahydrofuran / -78 °C

7: 84.4 percent / 1.) O₃, 2.) aq. Me₂S / methanol; CH₂Cl₂ / 6.5 h / -78 °C

With hydrogenchloride; methanol; dmap; sodium tetrahydroborate; dilithium tetrachlorocuprate; dimethylsulfide; sulfuric acid; ozone; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene; tert-butyl alcohol;
DOI:10.1021/jm00015a009