N-phenyl-3-(p-fluorophenyl)-4-[2-amino-4-(4-hydroxyphenyl)pyrimidin-6-yl]pyrazole

Base Information

Chemical Name:N-phenyl-3-(p-fluorophenyl)-4-[2-amino-4-(4-hydroxyphenyl)pyrimidin-6-yl]pyrazole
CAS No.:1356032-31-9
Molecular Formula:C₂₅H₁₈FN₅O
Molecular Weight:423.449
Hs Code.:

Synonyms:N-phenyl-3-(p-fluorophenyl)-4-[2-amino-4-(4-hydroxyphenyl)pyrimidin-6-yl]pyrazole

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Chemical Property of N-phenyl-3-(p-fluorophenyl)-4-[2-amino-4-(4-hydroxyphenyl)pyrimidin-6-yl]pyrazole

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Technology Process of N-phenyl-3-(p-fluorophenyl)-4-[2-amino-4-(4-hydroxyphenyl)pyrimidin-6-yl]pyrazole

There total 3 articles about N-phenyl-3-(p-fluorophenyl)-4-[2-amino-4-(4-hydroxyphenyl)pyrimidin-6-yl]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1356031-90-7
N-phenyl-3-(p-fluorophenyl)-4-(1-p-hydroxyphenyl-2-propen-1-one-3-yl)pyrazole

: 50-01-1
guanidine hydrochloride

: 1356032-31-9
N-phenyl-3-(p-fluorophenyl)-4-[2-amino-4-(4-hydroxyphenyl)pyrimidin-6-yl]pyrazole

Guidance literature:: With potassium hydroxide; for 12h; Reflux;
DOI:10.1016/j.bmcl.2011.10.059

Reference yield:

: 99-93-4
4-Hydroxyacetophenone

: 1356032-31-9
N-phenyl-3-(p-fluorophenyl)-4-[2-amino-4-(4-hydroxyphenyl)pyrimidin-6-yl]pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 24 h

2: potassium hydroxide / 12 h / Reflux

With potassium hydroxide; In ethanol; 1: Claisen condensation;
DOI:10.1016/j.bmcl.2011.10.059

Reference yield:

: 36640-40-1
3-(4-fluorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde

: 1356032-31-9
N-phenyl-3-(p-fluorophenyl)-4-[2-amino-4-(4-hydroxyphenyl)pyrimidin-6-yl]pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 24 h

2: potassium hydroxide / 12 h / Reflux

With potassium hydroxide; In ethanol; 1: Claisen condensation;
DOI:10.1016/j.bmcl.2011.10.059