2-N-benzyloxycarbonylamino-2-tert-butyloxycarbonyl-adamantane

Base Information

• Chemical Name: 2-N-benzyloxycarbonylamino-2-tert-butyloxycarbonyl-adamantane
• CAS No.: 184165-29-5
• Molecular Formula: C₂₃H₃₁NO₄
• Molecular Weight: 385.503
• Mol file: 184165-29-5.mol

Synonyms:2-N-benzyloxycarbonylamino-2-tert-butyloxycarbonyl-adamantane

Chemical Property of 2-N-benzyloxycarbonylamino-2-tert-butyloxycarbonyl-adamantane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-N-benzyloxycarbonylamino-2-tert-butyloxycarbonyl-adamantane

There total 4 articles about 2-N-benzyloxycarbonylamino-2-tert-butyloxycarbonyl-adamantane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-N-benzyloxycarbonylamino-2-hydroxycarbonyl-adamantane (144876-66-4) + N,N-dimethylformamide di-tert-butyl acetal (36805-97-7) → 2-N-benzyloxycarbonylamino-2-tert-butyloxycarbonyl-adamantane (184165-29-5)

Guidance literature:

In toluene; at 110 ℃; for 10h;

DOI:10.1016/S0968-0896(02)00342-5

Reference yield:

2-amino-2-adamantanecarboxylic acid (42381-05-5) → 2-N-benzyloxycarbonylamino-2-tert-butyloxycarbonyl-adamantane (184165-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH

2: 49 percent / toluene / 10 h / 110 °C

With potassium hydroxide; In toluene;

DOI:10.1016/S0968-0896(02)00342-5

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → 2-N-benzyloxycarbonylamino-2-tert-butyloxycarbonyl-adamantane (184165-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH

2: 49 percent / toluene / 10 h / 110 °C

With potassium hydroxide; In toluene;

DOI:10.1016/S0968-0896(02)00342-5

upstream raw materials:

2-N-benzyloxycarbonylamino-2-hydroxycarbonyl-adamantane

N,N-dimethylformamide di-tert-butyl acetal

2-amino-2-adamantanecarboxylic acid

benzyl chloroformate

Downstream raw materials:

N-[(2-tert-butyloxycarbonyl)-2-adamantyl] [(2S)-2-amino-3-(4-tert-butyloxyphenyl)]propanamide

N-[(2-tert-butyloxycarbonyl)-2-adamantyl] (2S)-2-N-(9-fluorenylmethyloxycarbonyl)amino-3-(4-tert-butyloxyphenyl)propanamide

N-{(2S)-1-[2-(tert-butyloxycarbonyl)adamantyl-2-amino]-3-(4-tert-butyloxyphenyl)-1-oxo-propan-2-yl} 1-{6-[N,N'-bis(tert-butyloxycarbonyl)guanidino]hexyl}-6-{[5-N,N'-bis(tert-butyloxycarbonyl)guanidino]pentyloxy}indole-2-carboxamide