2-[2,4-Bis-[bis-(4-tert-butyl-phenyl)-methyl]-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-2-ol

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Chemical Name:2-[2,4-Bis-[bis-(4-tert-butyl-phenyl)-methyl]-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-2-ol
CAS No.:138956-18-0
Molecular Formula:C₅₄H₇₀O₂
Molecular Weight:751.149
Hs Code.:

Synonyms:2-[2,4-Bis-[bis-(4-tert-butyl-phenyl)-methyl]-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-2-ol

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Chemical Property of 2-[2,4-Bis-[bis-(4-tert-butyl-phenyl)-methyl]-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-2-ol

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Technology Process of 2-[2,4-Bis-[bis-(4-tert-butyl-phenyl)-methyl]-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-2-ol

There total 7 articles about 2-[2,4-Bis-[bis-(4-tert-butyl-phenyl)-methyl]-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 138956-17-9
1,1,7,7-Tetrakis-(4-tert-butyl-phenyl)-3,3,5,5-tetramethyl-5,7-dihydro-1H,3H-benzo[1,2-c;4,5-c']difuran

: 138956-18-0
2-[2,4-Bis-[bis-(4-tert-butyl-phenyl)-methyl]-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-2-ol

Guidance literature:: With lithium; In tetrahydrofuran; for 144h;
DOI:10.1021/jo00032a030

Reference yield:

: 15796-82-4
4,4'-di-tert-butylbenzophenone

: 138956-18-0
2-[2,4-Bis-[bis-(4-tert-butyl-phenyl)-methyl]-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1) n-BuLi / 1) hexane, ether, -15 to -12 deg C, 1 h, 2) hexane, ether, -12 to 10 deg C, 5 h

2: 1) n-BuLi / 1) hexane, ether, -15 to -10 deg C, 1 h, 2) hexane, ether, -12 deg C to RT, 12 h

3: 1) Hg(OAc)2, 2) 3M NaOH, NaBH₄ / 1) THF, H₂O, 12 h, 2) THF, H₂O, 30 min, RT

4: 77 percent / Li / tetrahydrofuran / 144 h

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; mercury(II) diacetate; lithium; In tetrahydrofuran;
DOI:10.1021/jo00032a030

Reference yield:

: 90766-77-1
dimethyl 4,6-dibromobenzene-1,3-dioate

: 138956-18-0
2-[2,4-Bis-[bis-(4-tert-butyl-phenyl)-methyl]-5-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 54 percent / diethyl ether; tetrahydrofuran / 5 h / 0 deg C to RT

2: 92 percent / HCOOH, H₂SO₄ / 1 h / Heating

3: 1) n-BuLi / 1) hexane, ether, -15 to -12 deg C, 1 h, 2) hexane, ether, -12 to 10 deg C, 5 h

4: 1) n-BuLi / 1) hexane, ether, -15 to -10 deg C, 1 h, 2) hexane, ether, -12 deg C to RT, 12 h

5: 1) Hg(OAc)2, 2) 3M NaOH, NaBH₄ / 1) THF, H₂O, 12 h, 2) THF, H₂O, 30 min, RT

6: 77 percent / Li / tetrahydrofuran / 144 h

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; formic acid; sulfuric acid; mercury(II) diacetate; lithium; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00032a030