Technology Process of 4-oxo-N-tritylbutanamide
There total 4 articles about 4-oxo-N-tritylbutanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-hydroxy-N-tritylbutanamide;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -60 ℃;
for 2.25h;
With
triethylamine;
In
dichloromethane;
DOI:10.1016/j.bmcl.2012.07.011
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium borohydride / tetrahydrofuran; ethanol / 20 °C
2: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2.25 h / -60 °C
With
lithium borohydride; oxalyl dichloride; dimethyl sulfoxide;
In
tetrahydrofuran; ethanol; dichloromethane;
2: Swern oxidation / 2: Swern oxidation;
DOI:10.1016/j.bmcl.2012.07.011
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 20 °C
2.1: potassium hydroxide / ethanol / 48 h / Reflux
2.2: pH 2
3.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / 0 - 20 °C
4.1: dipyridinium dichromate / dichloromethane / 2 h / 20 °C / Inert atmosphere
With
sodium tetrahydroborate; dipyridinium dichromate; boron trifluoride diethyl etherate; potassium carbonate; potassium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/acs.jmedchem.9b00413