1195771-44-8

Basic information

• Product Name: methyl 4-oxo-4-(tritylamino)butanoate
• Synonyms: methyl 4-oxo-4-(tritylamino)butanoate
• CAS NO: 1195771-44-8
• Molecular Weight: 373.452
• Mol File: 1195771-44-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4-oxo-4-(tritylamino)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-oxo-4-(tritylamino)butanoate(1195771-44-8)
• EPA Substance Registry System: methyl 4-oxo-4-(tritylamino)butanoate(1195771-44-8)

Safety Data

• Hazardous Substances Data: 1195771-44-8(Hazardous Substances Data)

Upstream product

• 3878-55-5 methyl hydrogen succinate 
• 5824-40-8 Triphenylmethylamin 

Downstream Products

• 159492-89-4 4-oxo-N-tritylbutanamide 
• 1394940-70-5 C₄₃H₃₉N₂O₆P 
• 1394940-71-6 C₄₅H₄₃N₂O₈P 
• 1394940-72-7 C₅₁H₅₅N₂O₆P 
• 1394940-73-8 C₄₇H₄₇N₂O₆P 
• 1394940-94-3 C₃₅H₃₃N₂O₄P 
• 1394940-95-4 C₃₇H₃₇N₂O₆P 
• 1394940-89-6 C₆₂H₇₃N₄O₁₀P 
• 1394940-98-7 C₄₁H₄₄N₃O₅P 
• 1394940-99-8 C₄₃H₄₈N₃O₇P 
• 1394941-00-4 C₄₉H₆₀N₃O₅P 
• 1394941-01-5 C₄₅H₅₂N₃O₅P 
• 102560-84-9 4-hydroxy-N-tritylbutanamide 

Relevant articles and documents

The development of first Staphylococcus aureus SplB protease inhibitors: Phosphonic analogues of glutamine

Produced by Staphylococcus aureus, SplB belongs to the chymotrypsin-like serine protease family. Since the biological role of SplB protease is unknown, the design and application of its specific inhibitors may help to reveal the function of this enzyme. Until now no SplB inhibitors have been reported. Herein, we present the design and synthesis of novel α-aminophosphonic analogues of glutamine, as well as their peptidyl derivatives. The inhibitory effects of these compounds towards the newly discovered SplB serine protease from S. aureus are characterized. We have also investigated the influence of aromatic ester substituents on inhibitory potency towards SplB. One of the compounds - Cbz-Glu-Leu-GlnP(OC6H4-4-O-CH 3)2 - displayed an apparent second-order inhibition rate value of 1400 M-1 s-1.