Technology Process of C48H58N10O5
There total 7 articles about C48H58N10O5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-2,5-dioxopyrrolidin-1-yl (2-azido-3-phenylpropyl)carbamate;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 0.5h;
under 760.051 Torr;
Microwave irradiation;
solid phase reaction;
With
trimethylphosphane;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
at 70 ℃;
for 1h;
under 760.051 Torr;
Microwave irradiation;
solid phase reaction;
benzyl isothiocyanate;
Further stages;
DOI:10.1021/ol3012106
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrazine hydrate / methanol / 4 h / Reflux
2.1: dichloromethane / 3 h
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 70 °C / 760.05 Torr / Microwave irradiation; solid phase reaction
3.2: 1 h / 70 °C / 760.05 Torr / Microwave irradiation; solid phase reaction
With
hydrazine hydrate; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
3.2: Staudinger reduction;
DOI:10.1021/ol3012106
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dichloromethane / 3 h
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 70 °C / 760.05 Torr / Microwave irradiation; solid phase reaction
2.2: 1 h / 70 °C / 760.05 Torr / Microwave irradiation; solid phase reaction
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
2.2: Staudinger reduction;
DOI:10.1021/ol3012106
