(3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid

Base Information

Chemical Name:(3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid
CAS No.:212758-01-5
Molecular Formula:C₁₁H₁₀F₃NO₆
Molecular Weight:309.199
Hs Code.:

Synonyms:(3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid

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Chemical Property of (3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid

Chemical Property:

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Technology Process of (3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid

There total 6 articles about (3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 212757-98-7
(3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid methyl ester

: 212758-01-5
(3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid

Guidance literature:: With protease from Bacillus licheniformis; In N,N-dimethyl-formamide; at 37 ℃; Yield given; pH 7, overnight;
DOI:10.1021/jo980233x

Reference yield:

: 171738-31-1
4-methoxy-3,5-diisopropyloxybenzaldehyde

: 212758-01-5
(3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: NH₃ / methanol / 5 h / 45 °C

2: 1.) HCl gas, 2.) SOCl₂ / 1.) room temperature, 12 h, 2.) 55 deg C, 3 h

3: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

4: 50 percent / BCl₃ / hexane / Ambient temperature

5: protease from Bacillus licheniformis / dimethylformamide / 37 °C / pH 7, overnight

With hydrogenchloride; thionyl chloride; protease from Bacillus licheniformis; ammonia; boron trichloride; triethylamine; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo980233x

Reference yield:

: 171738-30-0
methyl 3,5-diisopropoxy-4-methoxybenzoate

: 212758-01-5
(3,5-Dihydroxy-4-methoxy-phenyl)-(2,2,2-trifluoro-acetylamino)-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LAH, 2.) PDC / 1.) THF, 2.) CH₂Cl₂

2: NH₃ / methanol / 5 h / 45 °C

3: 1.) HCl gas, 2.) SOCl₂ / 1.) room temperature, 12 h, 2.) 55 deg C, 3 h

4: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

5: 50 percent / BCl₃ / hexane / Ambient temperature

6: protease from Bacillus licheniformis / dimethylformamide / 37 °C / pH 7, overnight

With hydrogenchloride; lithium aluminium tetrahydride; dipyridinium dichromate; thionyl chloride; protease from Bacillus licheniformis; ammonia; boron trichloride; triethylamine; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo980233x