171738-31-1

Basic information

• Product Name: Benzaldehyde, 4-methoxy-3,5-bis(1-methylethoxy)-
• CAS NO: 171738-31-1
• Molecular Formula: C14H20O4
• Molecular Weight: 252.31
• Mol File: 171738-31-1.mol

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-methoxy-3,5-bis(1-methylethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-methoxy-3,5-bis(1-methylethoxy)-(171738-31-1)
• EPA Substance Registry System: Benzaldehyde, 4-methoxy-3,5-bis(1-methylethoxy)-(171738-31-1)

Safety Data

• Hazardous Substances Data: 171738-31-1(Hazardous Substances Data)

Upstream product

• 24093-81-0 methyl 3,5-dihydroxy-4-methoxybenzoate 
• 4248-19-5 tert-butyl carbazate 
• 71-23-8 propan-1-ol 
• 171738-30-0 methyl 3,5-diisopropoxy-4-methoxybenzoate 
• 918446-55-6 (3,5-Diisopropoxy-4-methoxy-phenyl)-methanol 

Downstream Products

• 217494-26-3 (R)-tert-Butoxycarbonylamino-(3,5-diisopropoxy-4-methoxy-phenyl)-acetic acid allyl ester 
• 178744-38-2 (R)-N-(t-butoxycarbonyl)-(3,5-diisopropyloxy-4-methoxyphenyl)glycine 
• 171738-35-5 (R)-(3,5-Diisopropoxy-4-methoxy-phenyl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid allyl ester 
• 171738-34-4 (R)-Amino-(3,5-diisopropoxy-4-methoxy-phenyl)-acetic acid allyl ester 
• 1026696-96-7 Amino-(3,5-diisopropoxy-4-methoxy-phenyl)-acetonitrile 
• 171738-32-2 (3,5-bisispropyloxy-4-methoxy-phenyl)-(2-hydroxy-1-phenyl-ethylamino)-acetonitrile 
• 918446-55-6 (3,5-Diisopropoxy-4-methoxy-phenyl)-methanol 
• 178744-34-8 C₄₅H₄₉F₂N₇O₁₆ 
• 178744-42-8 (S)-2-[(R)-2-[(R)-2-tert-Butoxycarbonylamino-2-(3,5-diisopropoxy-4-methoxy-phenyl)-acetylamino]-2-(4-methoxy-phenyl)-acetylamino]-3-(4-fluoro-3-nitro-phenyl)-propionic acid methyl ester 
• 217494-28-5 [2-(4-benzyl-2-oxo-oxazolidin-3-yl)-1-(3,5-bisisopropyloxy-4-methoxy-phenyl)-2-oxo-ethyl]carbamic acid tert-butyl ester 
• 178744-37-1 (R)-3-[(R)-2-Azido-2-(3,5-diisopropoxy-4-methoxy-phenyl)-acetyl]-4-benzyl-oxazolidin-2-one 
• 178744-36-0 (R)-4-Benzyl-3-[2-(3,5-diisopropoxy-4-methoxy-phenyl)-acetyl]-oxazolidin-2-one 
• 178744-35-9 3,5-diisopropyloxy-4-methoxyphenyl acetic acid 

Relevant articles and documents

Synthesis of β-amino-α-hydroxy esters and β-amino-α- azido ester by sharpless asymmetric aminohydroxylation, byproducts analysis

(Chemical Equation Presented) Synthesis of enantiomerically pure β-amino-α-hydroxy esters (1, 2) and β-amino-α-azido ester (3) using Sharpless AA as a key step is described. A hitherto unreported side reaction, the oxidation of the β-hydroxy-α-amino ester

Sulfinimine-mediated asymmetric synthesis of (R)-(4-methoxy-3,5-dihydroxyphenyl)glycine: The central amino acid of vancomycin and related agents

The sulfinimine asymmetric Strecker synthesis, the addition of ethyl aluminum cyano alkoxide, 'EtAl(OR)CN' to sulfinimine 10, has been applied to a concise highly efficient four-step enantioselective synthesis of (R)-(4-methoxy-3,5-dihydroxyphenyl)glycine (3) and its derivatives in >97% ee. These epimerization-sensitive arylglycines are precursors of the key central amino acid of vancomycin and related glycopeptide antibiotics.

Asymmetric Synthesis of (2S,3R) β-(4-F-3-NO2) phenyl Serine, D-(R)-4-methoxy-3,5-Bis tButyldimethylsiloxy Phenylglycine and Their Assemblage to C-O-D Ring of Vancomycin

The asymmetric synthesis of two appropriately functionalyzed non-proteinogenic amino acids 2 and 3 needed for the total synthesis of vancomycin was described.The assemblage of these amino acids into linear tripeptide followed by biary ether formation via intramolecular SNAr reaction led to the fully functionalized C-O-D ring vancomycin.