N-[5-acetyl-4-(4-chloro-phenyl)-2-cyano-6-methyl-thieno[2,3-b]pyridin-3-yl]-formimidic acid ethyl ester

Base Information

• Chemical Name: N-[5-acetyl-4-(4-chloro-phenyl)-2-cyano-6-methyl-thieno[2,3-b]pyridin-3-yl]-formimidic acid ethyl ester
• CAS No.: 620625-82-3
• Molecular Formula: C₂₀H₁₆ClN₃O₂S
• Molecular Weight: 397.885
• Mol file: 620625-82-3.mol

Synonyms:N-[5-acetyl-4-(4-chloro-phenyl)-2-cyano-6-methyl-thieno[2,3-b]pyridin-3-yl]-formimidic acid ethyl ester

Chemical Property of N-[5-acetyl-4-(4-chloro-phenyl)-2-cyano-6-methyl-thieno[2,3-b]pyridin-3-yl]-formimidic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[5-acetyl-4-(4-chloro-phenyl)-2-cyano-6-methyl-thieno[2,3-b]pyridin-3-yl]-formimidic acid ethyl ester

There total 3 articles about N-[5-acetyl-4-(4-chloro-phenyl)-2-cyano-6-methyl-thieno[2,3-b]pyridin-3-yl]-formimidic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

orthoformic acid triethyl ester (122-51-0) + 5-acetyl-3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carbonitrile (380638-23-3) → N-[5-acetyl-4-(4-chloro-phenyl)-2-cyano-6-methyl-thieno[2,3-b]pyridin-3-yl]-formimidic acid ethyl ester (620625-82-3)

Guidance literature:

In acetic anhydride; for 3h; Heating;

Reference yield:

5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-2<1H>pyridinethione (103868-29-7) → N-[5-acetyl-4-(4-chloro-phenyl)-2-cyano-6-methyl-thieno[2,3-b]pyridin-3-yl]-formimidic acid ethyl ester (620625-82-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / NaOAc*3H₂O / ethanol / 2 h / Heating

2: NaOAc*3H₂O / ethanol / 2 h / Heating

3: 90 percent / acetic anhydride / 3 h / Heating

With sodium acetate; In ethanol; acetic anhydride; 2: Thorpe-Ziegler cyclization;

Reference yield:

5-acetyl-4-(4-chloro-phenyl)-2-cyanomethylsulfanyl-6-methyl-nicotinonitrile (620625-68-5) → N-[5-acetyl-4-(4-chloro-phenyl)-2-cyano-6-methyl-thieno[2,3-b]pyridin-3-yl]-formimidic acid ethyl ester (620625-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOAc*3H₂O / ethanol / 2 h / Heating

2: 90 percent / acetic anhydride / 3 h / Heating

With sodium acetate; In ethanol; acetic anhydride; 1: Thorpe-Ziegler cyclization;

upstream raw materials:

orthoformic acid triethyl ester

5-acetyl-3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carbonitrile

5-acetyl-6-methyl-4-(4-chlorophenyl)-3-cyano-2<1H>pyridinethione

5-acetyl-4-(4-chloro-phenyl)-2-cyanomethylsulfanyl-6-methyl-nicotinonitrile

Downstream raw materials:

1-[3-Amino-9-(4-chloro-phenyl)-4-imino-7-methyl-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone