Technology Process of (2R,3R,4aR,8S,8aS)-5-(benzyloxy)-2,3,8-trimethoxy-2,3-dimethylhexahydro-2H-pyrano[3,4-b][1,4]dioxine
There total 3 articles about (2R,3R,4aR,8S,8aS)-5-(benzyloxy)-2,3,8-trimethoxy-2,3-dimethylhexahydro-2H-pyrano[3,4-b][1,4]dioxine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C18H26O7;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.25h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran;
at 0 ℃;
for 8h;
Inert atmosphere;
DOI:10.1016/j.tet.2013.07.009
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetyl chloride / 0 °C
1.2: 120 h / 0 - 20 °C
2.1: trimethyl orthoformate / methanol / 12 h / Reflux
3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
3.2: 8 h / 0 °C / Inert atmosphere
With
sodium hydride; acetyl chloride; trimethyl orthoformate;
In
tetrahydrofuran; methanol;
DOI:10.1016/j.tet.2013.07.009
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: trimethyl orthoformate / methanol / 12 h / Reflux
2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
2.2: 8 h / 0 °C / Inert atmosphere
With
sodium hydride; trimethyl orthoformate;
In
tetrahydrofuran; methanol;
DOI:10.1016/j.tet.2013.07.009
