Technology Process of cyclo[Phe-Oxz(Ser)-Orn(Cbz)-Oxz(Ser)]2
There total 9 articles about cyclo[Phe-Oxz(Ser)-Orn(Cbz)-Oxz(Ser)]2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 48h;
Inert atmosphere;
DOI:10.1039/c0ob01072c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium carbonate / 1,4-dioxane; water / 0 - 20 °C
2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere
3: water; sodium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C
4: pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere
With
pentafluorophenyl diphenyl-phosphinate; water; sodium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01072c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 20 °C / Inert atmosphere
2: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere
3: water; sodium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C
4: pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere
With
hydrogenchloride; pentafluorophenyl diphenyl-phosphinate; water; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01072c
