3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionic acid (1R,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl ester

Base Information

Chemical Name:3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionic acid (1R,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl ester
CAS No.:536739-85-2
Molecular Formula:C₃₅H₄₂O₇
Molecular Weight:574.714
Hs Code.:

Synonyms:3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionic acid (1R,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl ester

Suppliers and Price of 3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionic acid (1R,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionic acid (1R,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionic acid (1R,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl ester

There total 1 articles about 3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionic acid (1R,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 102208-53-7
(3R,4R,5R)-5-hydroxy-3,4,6-tribenzyloxy-1-hexene

: 173152-85-7
(R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionic acid

: 536739-85-2
3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionic acid (1R,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/ol034363q

Reference yield:

: 536739-85-2
3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionic acid (1R,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl ester

: (2R,3S,4R)-3,4-Bis-benzyloxy-2-benzyloxymethyl-6-[2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-3,4-dihydro-2H-pyran

Guidance literature:: Multi-step reaction with 2 steps

1: TiCl₄; TMEDA; Zn / PbCl₂ / CH₂Cl₂; tetrahydrofuran / 1 h / 60 °C

2: [N,N'-Mes₂-imidazolidin-2-yl]Ru=CHPhCl₂(PCy₃) / toluene / 3 h / 60 °C

With N,N,N,N,-tetramethylethylenediamine; titanium tetrachloride; zinc; tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; lead(II) chloride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ol034363q

Reference yield:

: 536739-85-2
3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-propionic acid (1R,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-pent-4-enyl ester

: 536739-93-2
(2S,3S,4R,5R,6R)-4,5-Bis-benzyloxy-6-benzyloxymethyl-2-[2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-tetrahydro-pyran-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: TiCl₄; TMEDA; Zn / PbCl₂ / CH₂Cl₂; tetrahydrofuran / 1 h / 60 °C

2.1: [N,N'-Mes₂-imidazolidin-2-yl]Ru=CHPhCl₂(PCy₃) / toluene / 3 h / 60 °C

3.1: BH₃ / toluene; tetrahydrofuran / 3 h / 0 °C

3.2: 279 mg / 1 M NaOH; 30 percent H₂O₂ / toluene; tetrahydrofuran; H₂O / 2 h / 0 - 20 °C

With N,N,N,N,-tetramethylethylenediamine; borane; titanium tetrachloride; zinc; tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; lead(II) chloride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ol034363q