methyl 2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoate

Base Information

• Chemical Name: methyl 2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoate
• CAS No.: 1057653-07-2
• Molecular Formula: C₁₄H₁₂ClNO₃S
• Molecular Weight: 309.773
• Mol file: 1057653-07-2.mol

Synonyms:methyl 2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoate

Chemical Property of methyl 2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoate

There total 1 articles about methyl 2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-Chlorothiophene-2-carboxylic acid (24065-33-6) + methyl 2-(aminomethyl)benzoate hydrochloride salt (849020-92-4) → methyl 2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoate (1057653-07-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 28h;

DOI:10.1016/j.bmc.2011.01.035

Reference yield: 100.0%

methyl 2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoate (1057653-07-2) → 2-{[(5-chlorothiophen-2-yl)carbonyl]aminomethyl}benzoic acid (1057653-08-3)

Guidance literature:

methyl 2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoate; With aluminum (III) chloride; dimethylsulfide; In dichloromethane; at 20 ℃; for 2h;

With hydrogenchloride; In water;

DOI:10.1016/j.bmc.2011.01.035

Reference yield:

methyl 2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoate (1057653-07-2) → tert-butyl 2-(2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoylamino)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylate (1057650-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aluminum (III) chloride; dimethylsulfide / dichloromethane / 2 h / 20 °C

1.2: ice

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

With aluminum (III) chloride; dimethylsulfide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2011.01.035

upstream raw materials:

5-Chlorothiophene-2-carboxylic acid

methyl 2-(aminomethyl)benzoate hydrochloride salt

Downstream raw materials:

2-{[(5-chlorothiophen-2-yl)carbonyl]aminomethyl}benzoic acid

tert-butyl 2-(2-{[(5-chlorothiophen-2-yl)carbonylamino]methyl}benzoylamino)-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylate

N-[2-(4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-ylcarbamoyl)benzyl]-5-chlorothiophene-2-carboxamide hydrochloride

N-[2-(4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-ylcarbamoyl)benzyl]-5-chlorothiophene-2-carboxamide

Refernces