(1E,3E)-tert-butyl benzyl(6,6,6-trifluoro-5-oxohexa-1,3-dienyl)carbamate

Base Information

Chemical Name:(1E,3E)-tert-butyl benzyl(6,6,6-trifluoro-5-oxohexa-1,3-dienyl)carbamate
CAS No.:1338468-25-9
Molecular Formula:C₁₈H₂₀F₃NO₃
Molecular Weight:355.357
Hs Code.:

Synonyms:(1E,3E)-tert-butyl benzyl(6,6,6-trifluoro-5-oxohexa-1,3-dienyl)carbamate

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Chemical Property of (1E,3E)-tert-butyl benzyl(6,6,6-trifluoro-5-oxohexa-1,3-dienyl)carbamate

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Technology Process of (1E,3E)-tert-butyl benzyl(6,6,6-trifluoro-5-oxohexa-1,3-dienyl)carbamate

There total 4 articles about (1E,3E)-tert-butyl benzyl(6,6,6-trifluoro-5-oxohexa-1,3-dienyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1338468-24-8
tert-butyl N-benzyl-N-[(E)-3-hydroxybut-1-enyl]carbamate

: 407-25-0
trifluoroacetic anhydride

: 1338468-25-9
(1E,3E)-tert-butyl benzyl(6,6,6-trifluoro-5-oxohexa-1,3-dienyl)carbamate

: tert-butyl N-benzyl-N-[(1E)-buta-1.3-dienyl]carbamate

Guidance literature:: tert-butyl N-benzyl-N-[(E)-3-hydroxybut-1-enyl]carbamate; trifluoroacetic anhydride; With pyridine; dmap; In acetonitrile; for 0.416667h;

With triethylamine; In acetonitrile; for 2h; Reflux;
DOI:10.1016/j.tet.2011.08.026

Reference yield:

: 1338468-23-7
(E)-tert-butyl benzyl(3-oxobut-1-en-1-yl)carbamate

: 1338468-25-9
(1E,3E)-tert-butyl benzyl(6,6,6-trifluoro-5-oxohexa-1,3-dienyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; sodium tetrahydroborate / 1.25 h / 0 - 20 °C

2.1: pyridine; dmap / acetonitrile / 0.42 h

2.2: 2 h / Reflux

With pyridine; methanol; dmap; sodium tetrahydroborate; In acetonitrile;
DOI:10.1016/j.tet.2011.08.026

Reference yield:

: 100-46-9
benzylamine

: 1338468-25-9
(1E,3E)-tert-butyl benzyl(6,6,6-trifluoro-5-oxohexa-1,3-dienyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 2 h / Inert atmosphere

2.1: dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: methanol; sodium tetrahydroborate / 1.25 h / 0 - 20 °C

4.1: pyridine; dmap / acetonitrile / 0.42 h

4.2: 2 h / Reflux

With pyridine; methanol; dmap; sodium tetrahydroborate; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2011.08.026