1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-((2-hydroxyethyl)thio)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Chemical Name:1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-((2-hydroxyethyl)thio)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea
CAS No.:1610449-28-9
Molecular Formula:C₃₆H₃₆N₈O₄S
Molecular Weight:676.799
Hs Code.:

Synonyms:1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-((2-hydroxyethyl)thio)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Chemical Property of 1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-((2-hydroxyethyl)thio)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

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Technology Process of 1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-((2-hydroxyethyl)thio)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

There total 3 articles about 1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-((2-hydroxyethyl)thio)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610450-03-7
1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)urea

: 27122-79-8
2-((3-aminophenyl)thio)ethanol

: 1610449-28-9
1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-((2-hydroxyethyl)thio)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

Reference yield:

: 1573025-19-0
phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

: 1610449-28-9
1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-((2-hydroxyethyl)thio)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 58 h / 20 - 40 °C / Inert atmosphere

2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 4 h / 70 °C

With dmap; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 476011-71-9
4-(2-chloro-pyrimidin-4-yloxy)-naphthalen-1-ylamine

: 1610449-28-9
1-(3-(tert-butyl)-1-(6-methoxypyridin-3-yl)-1H-pyrazol-5-yl)-3-(4-((2-((3-((2-hydroxyethyl)thio)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / dichloromethane; tetrahydrofuran / 20 h / 20 °C

2: dmap / tetrahydrofuran / 58 h / 20 - 40 °C / Inert atmosphere

3: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 4 h / 70 °C

With dmap; sodium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;