phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

Base Information

• Chemical Name: phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate
• CAS No.: 1573025-19-0
• Molecular Formula: C₂₁H₁₄ClN₃O₃
• Molecular Weight: 391.813
• Mol file: 1573025-19-0.mol

Synonyms:phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

Chemical Property of phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate

There total 1 articles about phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-chloro-pyrimidin-4-yloxy)-naphthalen-1-ylamine (476011-71-9) + phenyl chloroformate (1885-14-9) → phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate (1573025-19-0)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; for 20h;

Reference yield:

3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-amine (1573025-18-9) + phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate (1573025-19-0) → 1-(4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)urea (1573025-21-4)

Guidance literature:

With dmap; In tetrahydrofuran; at 50 ℃; for 16h;

Reference yield:

phenyl (4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)carbamate (1573025-19-0) + (3-amino-5-(tert-butyl)-2-methoxyphenyl)dimethylphosphine oxide → 1-(5-(tert-butyl)-3-(dimethylphosphoryl)-2-methoxyphenyl)-3-(4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)urea

Guidance literature:

With triethylamine; In tetrahydrofuran; at 60 ℃;

upstream raw materials:

4-(2-chloro-pyrimidin-4-yloxy)-naphthalen-1-ylamine

phenyl chloroformate

Downstream raw materials:

1-(4-((2-chloropyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)urea

1-(4-((2-((7-methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)urea

1-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-((2-((2-oxoindolin-6-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea

3-methoxy-5-((4-((4-(3-(3-(2-methylbut-3-yn-2-yl)-1-(p-tolyl)-1H-pyrazol-5-yl)ureido)-naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide