acetic acid (R)-1-(4-ethynylphenyl)ethyl ester

Base Information

• Chemical Name: acetic acid (R)-1-(4-ethynylphenyl)ethyl ester
• CAS No.: 945451-10-5
• Molecular Formula: C₁₂H₁₂O₂
• Molecular Weight: 188.226
• Mol file: 945451-10-5.mol

Synonyms:acetic acid (R)-1-(4-ethynylphenyl)ethyl ester

Chemical Property of acetic acid (R)-1-(4-ethynylphenyl)ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of acetic acid (R)-1-(4-ethynylphenyl)ethyl ester

There total 4 articles about acetic acid (R)-1-(4-ethynylphenyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Iodoacetophenone (13329-40-3) → acetic acid (R)-1-(4-ethynylphenyl)ethyl ester (945451-10-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 53 percent / sodium borohydride / methanol / 2 h / 20 °C

2: 100 percent / CuI; PPh₃; triethylamine / bis(triphenylphosphine)palladium(II) dichloride / 4 h / 20 °C

3: 68 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

4: 650 mg / Novozyme-435; molecular sieves 4 Angstroem / tetrahydrofuran / 5 h / 40 °C / kinetic resolution

With sodium tetrahydroborate; copper(l) iodide; novozyme-435; 4 A molecular sieve; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol;

DOI:10.1039/b701281k

Reference yield:

1-(4-iodophenyl)ethanol (68120-56-9,104013-25-4,53207-29-7) → acetic acid (R)-1-(4-ethynylphenyl)ethyl ester (945451-10-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / CuI; PPh₃; triethylamine / bis(triphenylphosphine)palladium(II) dichloride / 4 h / 20 °C

2: 68 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

3: 650 mg / Novozyme-435; molecular sieves 4 Angstroem / tetrahydrofuran / 5 h / 40 °C / kinetic resolution

With copper(l) iodide; novozyme-435; 4 A molecular sieve; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran;

DOI:10.1039/b701281k

Reference yield:

1-(4-ethynylphenyl)ethanol (901793-04-2) + Isopropenyl acetate (108-22-5) → (S)-1-(4-ethynylphenyl)ethanol (945451-09-2) + acetic acid (R)-1-(4-ethynylphenyl)ethyl ester (945451-10-5)

Guidance literature:

With novozyme-435; 4 A molecular sieve; In tetrahydrofuran; at 40 ℃; for 5h; kinetic resolution;

DOI:10.1039/b701281k

upstream raw materials:

1-(4-ethynylphenyl)ethanol

Isopropenyl acetate

4-Iodoacetophenone

1-(4-iodophenyl)ethanol