1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

Base Information

• Chemical Name: 1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine
• CAS No.: 261896-47-3
• Molecular Formula: C₂₅H₃₀N₂O₃
• Molecular Weight: 406.525

Synonyms:1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

Chemical Property of 1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

There total 6 articles about 1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) + (R,E)-3-(5-methylhex-2-enoyl)-4-phenyl-1,3-oxazolidine-2-one (261896-46-2) → 1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine (261896-47-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; toluene; at 0 - 22 ℃;

DOI:10.1016/S0040-4020(01)00549-X

Reference yield: 57.3%

(R)-4-phenyl-3-(5-methylhex-2-enoyl)oxazolidin-2-one + N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine (93102-05-7) → 1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine (261896-47-3)

Guidance literature:

(R)-4-phenyl-3-(5-methylhex-2-enoyl)oxazolidin-2-one; N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine; In toluene; at 25 ℃; for 0.5h;

With trifluoroacetic acid; In dichloromethane; toluene; at 0 - 25 ℃; for 8h;

Reference yield:

(E)-5-methylhex-2-enoic acid chloride (81530-29-2,148826-71-5) → 1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine (261896-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h / 22 °C

1.2: 100 percent / tetrahydrofuran / 0 - 22 °C

2.1: 65 percent / TFA / toluene; CH₂Cl₂ / 0 - 22 °C

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/S0040-4020(01)00549-X

upstream raw materials:

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

(R,E)-3-(5-methylhex-2-enoyl)-4-phenyl-1,3-oxazolidine-2-one

(E)-5-methylhex-2-enoic acid chloride

(E)-5-methyl-2-hexenoic acid

Downstream raw materials:

(3S,4S)-4-(2'-methylprop-1'-yl)-3-pyrrolidine carboxylic acid

1-benzyl-4-(S)-isobutylpyrrolidine-3-(S)-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 261896-47-3 1-benzyl-4-(S)-isobutyl-3-(S)-[4'-(R)-phenyl-2'-oxazolidinon-3'-yl]carbonyl pyrrolidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send