5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-methyl-8-azanebularine

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Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-methyl-8-azanebularine
CAS No.:909907-42-2
Molecular Formula:C₃₇H₄₅N₅O₆Si
Molecular Weight:683.88
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-methyl-8-azanebularine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-methyl-8-azanebularine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-methyl-8-azanebularine

There total 6 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-methyl-8-azanebularine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 909907-41-1
5'-O-(4,4'-dimethoxytrityl)-6-methyl-8-azanebularine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 909907-42-2
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-methyl-8-azanebularine

: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(tert-butyldimethylsilyl)-6-methyl-8-azanebularine

Guidance literature:: With silver nitrate; triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/ol061354j

Reference yield:

: 909907-40-0
6-methyl-8-azanebularine

: 909907-42-2
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-methyl-8-azanebularine

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / pyridine; AgNO₃ / tetrahydrofuran / 17 h / 20 °C

2: 32 percent / AgNO₃; Et₃N / tetrahydrofuran / 24 h / 20 °C

With pyridine; silver nitrate; triethylamine; In tetrahydrofuran;
DOI:10.1021/ol061354j

Reference yield:

: 909907-32-0
2',3',5'-tri-O-acetyl-6-methyl-8-azanebularine

: 909907-42-2
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-6-methyl-8-azanebularine

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / NH₃; MeOH / 17 h / 4 °C

2: 70 percent / pyridine; AgNO₃ / tetrahydrofuran / 17 h / 20 °C

3: 32 percent / AgNO₃; Et₃N / tetrahydrofuran / 24 h / 20 °C

With pyridine; methanol; ammonia; silver nitrate; triethylamine; In tetrahydrofuran;
DOI:10.1021/ol061354j