(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2S,4S)-1-cyclohexylmethyl-2-hydroxy-4-methanesulfonylamino-5-methyl-hexyl)-amide

Base Information

Chemical Name:(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2S,4S)-1-cyclohexylmethyl-2-hydroxy-4-methanesulfonylamino-5-methyl-hexyl)-amide
CAS No.:140660-77-1
Molecular Formula:C₃₇H₆₃N₃O₈S
Molecular Weight:709.989
Hs Code.:

(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2S,4S)-1-cyclohexylmethyl-2-hydroxy-4-methanesulfonylamino-5-methyl-hexyl)-amide

Synonyms:(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2S,4S)-1-cyclohexylmethyl-2-hydroxy-4-methanesulfonylamino-5-methyl-hexyl)-amide

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Chemical Property of (S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2S,4S)-1-cyclohexylmethyl-2-hydroxy-4-methanesulfonylamino-5-methyl-hexyl)-amide

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Technology Process of (S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2S,4S)-1-cyclohexylmethyl-2-hydroxy-4-methanesulfonylamino-5-methyl-hexyl)-amide

There total 5 articles about (S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2S,4S)-1-cyclohexylmethyl-2-hydroxy-4-methanesulfonylamino-5-methyl-hexyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129921-93-3
2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

: 140660-77-1
(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2S,4S)-1-cyclohexylmethyl-2-hydroxy-4-methanesulfonylamino-5-methyl-hexyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) triethylamine, diphenylphosphoryl azide / 1.) toluene, 70 deg C, 1.5 h, 2.) toluene, reflux, 72 h

2: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 18 h / 3040 Torr

3: 91 percent / triethylamine / CH₂Cl₂ / 1.5 h / -10 °C

4: TFA / 1.) CH₂Cl₂, 0 deg C, 3.5 h, 2.a.) THF, H₂O, 0 deg C, 4 h, b.) THF, H₂O, RT, 12 h

5: 1-hydroxybenzotriazole hydrate (HOBT), 4-methylmorpholine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) / dimethylformamide / 1.) -23 deg C, 4 h, 2.) RT, 18 h

With 4-methyl-morpholine; diphenylphosphoranyl azide; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a007

Reference yield:

: 140660-63-5
(2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-<<(phenylmethoxy)carbonyl>amino>-3-methylbutane

: 140660-77-1
(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2S,4S)-1-cyclohexylmethyl-2-hydroxy-4-methanesulfonylamino-5-methyl-hexyl)-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / H₂ / 10percent Pd/C / ethyl acetate / 18 h / 3040 Torr

2: 91 percent / triethylamine / CH₂Cl₂ / 1.5 h / -10 °C

3: TFA / 1.) CH₂Cl₂, 0 deg C, 3.5 h, 2.a.) THF, H₂O, 0 deg C, 4 h, b.) THF, H₂O, RT, 12 h

4: 1-hydroxybenzotriazole hydrate (HOBT), 4-methylmorpholine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) / dimethylformamide / 1.) -23 deg C, 4 h, 2.) RT, 18 h

With 4-methyl-morpholine; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a007

Reference yield:

: 140660-66-8
(2S,4S,5S)-1-<3-(tert-butyloxycarbonyl)-2,2-dimethyl-4-(cyclohexylmethyl)-5-oxazolidinyl>-2-amino-3-methylbutane

: 140660-77-1
(S)-2-[(S)-1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-oxo-ethoxy]-hexanoic acid ((1S,2S,4S)-1-cyclohexylmethyl-2-hydroxy-4-methanesulfonylamino-5-methyl-hexyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / triethylamine / CH₂Cl₂ / 1.5 h / -10 °C

2: TFA / 1.) CH₂Cl₂, 0 deg C, 3.5 h, 2.a.) THF, H₂O, 0 deg C, 4 h, b.) THF, H₂O, RT, 12 h

3: 1-hydroxybenzotriazole hydrate (HOBT), 4-methylmorpholine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) / dimethylformamide / 1.) -23 deg C, 4 h, 2.) RT, 18 h

With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a007