2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

Base Information

Chemical Name:2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid
CAS No.:129921-93-3
Molecular Formula:C₂₃H₄₁NO₅
Molecular Weight:411.582
Hs Code.:

Synonyms:2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

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Chemical Property of 2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

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Technology Process of 2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

There total 5 articles about 2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 129921-92-2
3-(3-(3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)-2(R)-isopropyl-1-oxopropyl)-4(R)-methyl-5(S)-phenyl-2-oxazolidinone

: 129921-93-3
2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; for 20h; Ambient temperature;
DOI:10.1021/jo00001a083

Reference yield:

: 107599-99-5
(4R,5S)-(+)-3-[3-methyl-1-oxobut-1-yl]-4-methyl-5-phenyl-2-oxazolidinone

: 129921-93-3
2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

2: 84 percent / 1,2-dichloro-ethane / 1.) 48 h, reflux 2.) 18 h, reflux

3: 91 percent / tri-n-butyltin hydride / toluene / 2 h / Heating

4: 90 percent / lithium hydroxide monohydrate, 30percent aq. H₂O₂ / tetrahydrofuran; H₂O / 20 h / Ambient temperature

With lithium hydroxide; dihydrogen peroxide; tri-n-butyl-tin hydride; In tetrahydrofuran; water; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo00001a083

Reference yield:

: 117997-58-7
(S)-4-Cyclohexylmethyl-5-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 129921-93-3
2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

2: 84 percent / 1,2-dichloro-ethane / 1.) 48 h, reflux 2.) 18 h, reflux

3: 91 percent / tri-n-butyltin hydride / toluene / 2 h / Heating

4: 90 percent / lithium hydroxide monohydrate, 30percent aq. H₂O₂ / tetrahydrofuran; H₂O / 20 h / Ambient temperature

With lithium hydroxide; dihydrogen peroxide; tri-n-butyl-tin hydride; In tetrahydrofuran; water; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo00001a083