2-tert-Butoxycarbonylamino-3-{4,4'-dimethoxy-3'-[2-methoxycarbonyl-2-(2-trimethylsilanyl-ethoxycarbonylamino)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester

Base Information

Chemical Name:2-tert-Butoxycarbonylamino-3-{4,4'-dimethoxy-3'-[2-methoxycarbonyl-2-(2-trimethylsilanyl-ethoxycarbonylamino)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester
CAS No.:136896-87-2
Molecular Formula:C₃₉H₅₂N₂O₁₀Si
Molecular Weight:736.935
Hs Code.:

2-tert-Butoxycarbonylamino-3-{4,4'-dimethoxy-3'-[2-methoxycarbonyl-2-(2-trimethylsilanyl-ethoxycarbonylamino)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester

Synonyms:2-tert-Butoxycarbonylamino-3-{4,4'-dimethoxy-3'-[2-methoxycarbonyl-2-(2-trimethylsilanyl-ethoxycarbonylamino)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester

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Chemical Property of 2-tert-Butoxycarbonylamino-3-{4,4'-dimethoxy-3'-[2-methoxycarbonyl-2-(2-trimethylsilanyl-ethoxycarbonylamino)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester

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Technology Process of 2-tert-Butoxycarbonylamino-3-{4,4'-dimethoxy-3'-[2-methoxycarbonyl-2-(2-trimethylsilanyl-ethoxycarbonylamino)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester

There total 4 articles about 2-tert-Butoxycarbonylamino-3-{4,4'-dimethoxy-3'-[2-methoxycarbonyl-2-(2-trimethylsilanyl-ethoxycarbonylamino)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (Z)-2-tert-Butoxycarbonylamino-3-{4,4'-dimethoxy-3'-[(Z)-2-methoxycarbonyl-2-(2-trimethylsilanyl-ethoxycarbonylamino)-vinyl]-biphenyl-3-yl}-acrylic acid benzyl ester

: 136896-87-2
2-tert-Butoxycarbonylamino-3-{4,4'-dimethoxy-3'-[2-methoxycarbonyl-2-(2-trimethylsilanyl-ethoxycarbonylamino)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester

Guidance literature:: With (R,R)-(-)-1,2-bis[(o-methoxyphenyl)(phenyl) phosphino]ethane(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; In ethanol; at 40 ℃; for 72h; under 2660 Torr;

Reference yield:

: 94882-75-4
benzyl (2-t-butoxycarbonylamino)acrylate

: 136896-87-2
2-tert-Butoxycarbonylamino-3-{4,4'-dimethoxy-3'-[2-methoxycarbonyl-2-(2-trimethylsilanyl-ethoxycarbonylamino)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / Pd(OAc)2, Bu₄NCl, NaHCO₃ / dimethylformamide / 16 h / 85 °C

2: 77 percent / Pd(OAc)2, Bu₄NCl, NaHCO₃ / dimethylformamide / 16 h / 85 °C

3: 78 percent / H₂, BF₄ / ethanol / 72 h / 40 °C / 2660 Torr

With palladium diacetate; (R,R)-(-)-1,2-bis[(o-methoxyphenyl)(phenyl) phosphino]ethane(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 130247-00-6
3,3'-diiodo-4,4'-dimethoxybiphenyl

: 136896-87-2
2-tert-Butoxycarbonylamino-3-{4,4'-dimethoxy-3'-[2-methoxycarbonyl-2-(2-trimethylsilanyl-ethoxycarbonylamino)-ethyl]-biphenyl-3-yl}-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / Pd(OAc)2, Bu₄NCl, NaHCO₃ / dimethylformamide / 16 h / 85 °C

2: 77 percent / Pd(OAc)2, Bu₄NCl, NaHCO₃ / dimethylformamide / 16 h / 85 °C

3: 78 percent / H₂, BF₄ / ethanol / 72 h / 40 °C / 2660 Torr

With palladium diacetate; (R,R)-(-)-1,2-bis[(o-methoxyphenyl)(phenyl) phosphino]ethane(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; In ethanol; N,N-dimethyl-formamide;