(5S)-1-((3S)-1-(2-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-4-(tert-butoxy)-5-isobutyl-1H-pyrrol-2(5H)-one

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Chemical Name:(5S)-1-((3S)-1-(2-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-4-(tert-butoxy)-5-isobutyl-1H-pyrrol-2(5H)-one
CAS No.:1316848-29-9
Molecular Formula:C₂₇H₃₇N₃O₃
Molecular Weight:451.609
Hs Code.:

Synonyms:(5S)-1-((3S)-1-(2-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-4-(tert-butoxy)-5-isobutyl-1H-pyrrol-2(5H)-one

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Chemical Property of (5S)-1-((3S)-1-(2-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-4-(tert-butoxy)-5-isobutyl-1H-pyrrol-2(5H)-one

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Technology Process of (5S)-1-((3S)-1-(2-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-4-(tert-butoxy)-5-isobutyl-1H-pyrrol-2(5H)-one

There total 13 articles about (5S)-1-((3S)-1-(2-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-4-(tert-butoxy)-5-isobutyl-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 69358-30-1
(5S)-5-benzylpyrrolidine-2,4-dione

: 1316848-18-6
(S)-4-(tert-butoxy)-5-isobutyl-1-((S)-pyrrolidin-3-yl)-1H-pyrrol-2(5H)-one

: 1316848-29-9
(5S)-1-((3S)-1-(2-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-4-(tert-butoxy)-5-isobutyl-1H-pyrrol-2(5H)-one

Guidance literature:: With trimethyl orthoformate; In isopropyl alcohol; at 25 ℃; for 5h; Inert atmosphere;
DOI:10.1021/ja2033734

Reference yield: 74.0%

: 69358-30-1
(5S)-5-benzylpyrrolidine-2,4-dione

: C₁₇H₂₈N₂O₃

: 1316848-29-9
(5S)-1-((3S)-1-(2-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-4-(tert-butoxy)-5-isobutyl-1H-pyrrol-2(5H)-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; trimethyl orthoformate; In isopropyl alcohol; at 25 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jo400323k

Reference yield:

: 1316848-06-2
C₂₂H₃₄N₂O₄*ClH

: 1316848-29-9
(5S)-1-((3S)-1-(2-benzyl-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)pyrrolidin-3-yl)-4-(tert-butoxy)-5-isobutyl-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h / 75 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 25 °C / 760.05 Torr / Inert atmosphere

3: trimethyl orthoformate / isopropyl alcohol / 5 h / 25 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; trimethyl orthoformate; In tetrahydrofuran; methanol; isopropyl alcohol;
DOI:10.1021/ja2033734