69358-30-1

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 2033-24-1 cycl-isopropylidene malonate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 112700-41-1 (5S)-5-benzyl-1-(tert-butyloxycarbonyl)-4-hydroxy-1,5-dihydro-pyrrol-2-one 
• 112700-36-4 (2'S)-5-<(1-hydroxy-3-phenyl-2-t-butoxycarbonylamino)-propylidene>-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 109579-09-1 (5S)-5-benzyl-4-hydroxy-1-t-butoxycarbonylpyrrol-2(5H)-one 

Downstream Products

• 1373825-38-7 (S)-5-benzyl-3-(α-hydroxybenzylidene)-4-oxo-2-pyrrolidone 
• 1373825-58-1 (S)-5-benzyl-3-(α-hydroxybenzylidene)-4-oxo-2-pyrrolidone 
• 1373825-48-9 (S)-5-benzyl-3-(1-hydroxy-2-methylbutylidene)-4-oxo-2-pyrrolidone 
• 1373825-68-3 (S)-5-benzyl-3-(1-hydroxy-2-methylbutylidene)-4-oxo-2-pyrrolidone 
• 1373825-33-2 (S)-2-benzyl-5-oxo-2,5-dihydro-1H-3-pyrrolyl 2-methylbutanoate 
• 1373825-26-3 (S)-2-benzyl-5-oxo-2,5-dihydro-1H-3-pyrrolyl benzoate 

Relevant academic research and scientific papers

Bioactivity and Mode of Action of Bacterial Tetramic Acids

Microbially produced 3-acyltetramic acids display a diverse range of biological activities. The pyreudiones are new members of this class that were isolated from bacteria of the genus Pseudomonas. Here, we performed a structure-activity relationship study

Expanding the scope of oligo-pyrrolinone-pyrrolidines as protein-protein interface mimics

Oligo-pyrrolinone-pyrrolidines (generic structure 1) have the potential to interfere with protein-protein interactions (PPIs), but to reduce this to practice it is necessary to be able to synthesize these structures with a variety of different side chains

A synthetic approach to diverse 3-acyltetramic acids via O- to C-acyl rearrangement and application to the total synthesis of penicillenol series

For the efficient approach to medicinally important α-branched 3-acyltetramic acids, the key reaction of O- to C- acyl rearrangement using α-amino-acid-derived 4-O-acyltetramic acids was extensively examined in the presence of various metal salts. Use of

Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics

Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/β-turn/sheet motif.

Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones

Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the r