[2-(3,4-dimethoxyphenyl)ethyl]-[2-hydroxy-3-(1,2,3,4-tetrahydroquinolin-6-yloxy)propyl]carbamic acid tert-butylester

Base Information

• Chemical Name: [2-(3,4-dimethoxyphenyl)ethyl]-[2-hydroxy-3-(1,2,3,4-tetrahydroquinolin-6-yloxy)propyl]carbamic acid tert-butylester
• CAS No.: 1134191-03-9
• Molecular Formula: C₂₇H₃₈N₂O₆
• Molecular Weight: 486.609

Synonyms:[2-(3,4-dimethoxyphenyl)ethyl]-[2-hydroxy-3-(1,2,3,4-tetrahydroquinolin-6-yloxy)propyl]carbamic acid tert-butylester

Chemical Property of [2-(3,4-dimethoxyphenyl)ethyl]-[2-hydroxy-3-(1,2,3,4-tetrahydroquinolin-6-yloxy)propyl]carbamic acid tert-butylester

Chemical Property:

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Technology Process of [2-(3,4-dimethoxyphenyl)ethyl]-[2-hydroxy-3-(1,2,3,4-tetrahydroquinolin-6-yloxy)propyl]carbamic acid tert-butylester

There total 2 articles about [2-(3,4-dimethoxyphenyl)ethyl]-[2-hydroxy-3-(1,2,3,4-tetrahydroquinolin-6-yloxy)propyl]carbamic acid tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.2%

[3-(1-benzyl-1,2,3,4-tetrahydroquinolin-6-yloxy)-2-hydroxypropyl][2-(3,4-dimethoxyphenyl)ethyl]carbamic acid tert-butyl ester (1134191-04-0) → [2-(3,4-dimethoxyphenyl)ethyl]-[2-hydroxy-3-(1,2,3,4-tetrahydroquinolin-6-yloxy)propyl]carbamic acid tert-butylester (1134191-03-9)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 38 ℃; for 5h; under 2585.81 Torr;

DOI:10.1016/j.bmc.2008.11.030

Reference yield: 52.9%

di-tert-butyl dicarbonate (24424-99-5) + 1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(1,2,3,4-tetrahydroquinolin-6-yloxy)propan-2-ol (1134191-02-8) → [2-(3,4-dimethoxyphenyl)ethyl]-[2-hydroxy-3-(1,2,3,4-tetrahydroquinolin-6-yloxy)propyl]carbamic acid tert-butylester (1134191-03-9)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; at 0 - 30 ℃;

DOI:10.1016/j.bmc.2008.11.030

Reference yield: 66.0%

[2-(3,4-dimethoxyphenyl)ethyl]-[2-hydroxy-3-(1,2,3,4-tetrahydroquinolin-6-yloxy)propyl]carbamic acid tert-butylester (1134191-03-9) + 4-Fluorobenzenesulfonyl chloride (349-88-2) → [2-(3,4-dimethoxyphenyl)ethyl]-{3-[1-(4-fluorobenzenesulfonyl)-1,2,3,4-tetrahydroquinolin-6-yloxy]-2-hydroxypropyl}carbamic acid tert-butyl ester (1134191-06-2)

Guidance literature:

With sodium carbonate; In acetone; at 20 ℃;

DOI:10.1016/j.bmc.2008.11.030

upstream raw materials:

di-tert-butyl dicarbonate

1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(1,2,3,4-tetrahydroquinolin-6-yloxy)propan-2-ol

[3-(1-benzyl-1,2,3,4-tetrahydroquinolin-6-yloxy)-2-hydroxypropyl][2-(3,4-dimethoxyphenyl)ethyl]carbamic acid tert-butyl ester

Downstream raw materials:

[2-(3,4-dimethoxyphenyl)ethyl]-{2-hydroxy-3-[1-(2,4,6-triisopropylbenzenesulfonyl)-1,2,3,4-tetrahydroquinolin-6-yloxy]propyl}carbamic acid tert-butyl ester

[2-(3,4-dimethoxyphenyl)ethyl]-{3-[1-(4-fluorobenzenesulfonyl)-1,2,3,4-tetrahydroquinolin-6-yloxy]-2-hydroxypropyl}carbamic acid tert-butyl ester

[3-(1-benzenesulfonyl-1,2,3,4-tetrahydroquinolin-6-yloxy)-2-hydroxypropyl][2-(3,4-dimethoxyphenyl)ethyl]carbamicacid tert-butyl ester

[2-(3,4-dimethoxyphenyl)ethyl]-{2-hydroxy-3-[1-(naphthalene-2-sulfonyl)1,2,3,4-tetrahydroquinolin-6-yloxy]propyl}carbamic acid tert-butyl ester

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