(2E,6E,8E)-(4R,5R,10S,11R,12S)-11-(4-Methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-5-triphenylsilanyloxy-docosa-2,6,8-trienal

Base Information

Chemical Name:(2E,6E,8E)-(4R,5R,10S,11R,12S)-11-(4-Methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-5-triphenylsilanyloxy-docosa-2,6,8-trienal
CAS No.:1026506-42-2
Molecular Formula:C₅₄H₇₂O₄Si
Molecular Weight:813.249
Hs Code.:

Synonyms:(2E,6E,8E)-(4R,5R,10S,11R,12S)-11-(4-Methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-5-triphenylsilanyloxy-docosa-2,6,8-trienal

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Chemical Property of (2E,6E,8E)-(4R,5R,10S,11R,12S)-11-(4-Methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-5-triphenylsilanyloxy-docosa-2,6,8-trienal

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Technology Process of (2E,6E,8E)-(4R,5R,10S,11R,12S)-11-(4-Methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-5-triphenylsilanyloxy-docosa-2,6,8-trienal

There total 15 articles about (2E,6E,8E)-(4R,5R,10S,11R,12S)-11-(4-Methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-5-triphenylsilanyloxy-docosa-2,6,8-trienal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 361525-08-8
(2E,6E,8E)-(4R,5R,10S,11R,12S)-11-(4-Methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-5-triphenylsilanyloxy-docosa-2,6,8-trien-1-ol

: 1026506-42-2
(2E,6E,8E)-(4R,5R,10S,11R,12S)-11-(4-Methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-5-triphenylsilanyloxy-docosa-2,6,8-trienal

Guidance literature:: With manganese(IV) oxide; In dichloromethane;
DOI:10.1039/b305818b

Reference yield:

: 361525-06-6
1-Methoxy-4-[(1R,2S)-2-methyl-1-((S)-1-methyl-but-2-ynyl)-dodecyloxymethyl]-benzene

: 1026506-42-2
(2E,6E,8E)-(4R,5R,10S,11R,12S)-11-(4-Methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-5-triphenylsilanyloxy-docosa-2,6,8-trienal

Guidance literature:: Multi-step reaction with 3 steps

1.1: 9-BBN / tetrahydrofuran / 12 h / 20 °C

1.2: 88 percent / K₃PO₄ / PdCl₂(dppf) / tetrahydrofuran; dimethylformamide; H₂O / 0.5 h / 65 °C

2.1: 94 percent / DIBAL / CH₂Cl₂ / -78 °C

3.1: MnO₂ / CH₂Cl₂

With manganese(IV) oxide; 9-borabicyclo[3.3.1]nonane dimer; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; 1.2: Suzuki-Miyaura coupling;
DOI:10.1039/b305818b

Reference yield:

: 361525-03-3
(2E,6E)-(4R,5R)-7-Iodo-2,4,6-trimethyl-5-triphenylsilanyloxy-hepta-2,6-dienoic acid ethyl ester

: 1026506-42-2
(2E,6E,8E)-(4R,5R,10S,11R,12S)-11-(4-Methoxy-benzyloxy)-2,4,6,8,10,12-hexamethyl-5-triphenylsilanyloxy-docosa-2,6,8-trienal

Guidance literature:: Multi-step reaction with 3 steps

1.1: 9-BBN / tetrahydrofuran / 12 h / 20 °C

1.2: 88 percent / K₃PO₄ / PdCl₂(dppf) / tetrahydrofuran; dimethylformamide; H₂O / 0.5 h / 65 °C

2.1: 94 percent / DIBAL / CH₂Cl₂ / -78 °C

3.1: MnO₂ / CH₂Cl₂

With manganese(IV) oxide; 9-borabicyclo[3.3.1]nonane dimer; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; 1.2: Suzuki-Miyaura coupling;
DOI:10.1039/b305818b