(1r,1r)-methyl 4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxylate

Base Information

Chemical Name:(1r,1r)-methyl 4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxylate
CAS No.:1357279-05-0
Molecular Formula:C₁₇H₂₂N₂O₄S
Molecular Weight:350.439
Hs Code.:

Synonyms:(1r,1r)-methyl 4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxylate

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Chemical Property of (1r,1r)-methyl 4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxylate

Chemical Property:

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Technology Process of (1r,1r)-methyl 4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxylate

There total 1 articles about (1r,1r)-methyl 4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859850-75-2
1-methyl-1H-indole-5-sulfonyl chloride

: 62456-15-9
methyl trans-4-amino-cyclohexanecarboxylate

: 1357279-05-0
(1r,1r)-methyl 4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 591-50-4
iodobenzene

: 1357279-05-0
(1r,1r)-methyl 4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxylate

: 1357279-06-1
(1r,1r)-4-(1-methyl-2-phenyl-1H-indole-5-sulfonamido)cyclohexanecarboxylic acid

Guidance literature:: iodobenzene; (1r,1r)-methyl 4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxylate; With ortho-nitrobenzoic acid; silver(l) oxide; palladium diacetate; In N,N-dimethyl-formamide; at 40 ℃; for 16h; Inert atmosphere;

With water; sodium hydroxide; In acetonitrile; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=4 - 5;

Reference yield:

: 1357279-05-0
(1r,1r)-methyl 4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxylate

: 1357271-85-2
(1r,1r)-N-((R)-1-(4-fluorophenyl)ethyl)-4-(1-methyl-2-phenyl-1H-indole-5-sulfonamido)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver(l) oxide; ortho-nitrobenzoic acid / palladium diacetate / N,N-dimethyl-formamide / 16 h / 40 °C / Inert atmosphere

1.2: 2 h / 20 °C

1.3: pH 4 - 5

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

With ortho-nitrobenzoic acid; N-ethyl-N,N-diisopropylamine; HATU; silver(l) oxide; palladium diacetate; In N,N-dimethyl-formamide;