62456-15-9Relevant articles and documents
D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine
Shen, Yudao,McCorvy, John D.,Martini, Michael L.,Rodriguiz, Ramona M.,Pogorelov, Vladimir M.,Ward, Karen M.,Wetsel, William C.,Liu, Jing,Roth, Bryan L.,Jin, Jian
, p. 4755 - 4771 (2019/05/08)
Functionally selective G protein-coupled receptor ligands are valuable tools for deciphering the roles of downstream signaling pathways that potentially contribute to therapeutic effects versus side effects. Recently, we discovered both Gi/o-bi
Polycyclic Azetidines and Pyrrolidines via Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)-H Bonds
Zhao, Jie,Zhao, Xiao-Jing,Cao, Pei,Liu, Ji-Kai,Wu, Bin
supporting information, p. 4880 - 4883 (2017/09/23)
A novel strategy to construct complex polycyclic nitrogen-containing heterocycles from aliphatic amines via picolinamide-assisted palladium-catalyzed C-H bond activation reaction was reported. The reaction exhibits broad substrate scope for the synthesis of various azabicyclic scaffolds, including azetidines and tropane-class alkaloids. Application of this method to naturally occurring (-)-cis-myrtanylamine, an unprecedented type of carbon-carbon bond activation, in which the electron-pair involved initiates an intramolecular "SN2-like" displacement of a cyclopalladium-fragment from a tertiary center, is described.
Cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists
Burns, James Ford,Chen, Bin,Chen, Chien-An,Doller, Dario,Edelmenky, Eman,Jiang, Yu,Peterson, John M.,Sabio, Michael,Weiss, Jessie,White, Andrew D.,Wu, Lingyun,Bhardwaj, Rajinder,Chandrasena, Gamini,Boyle, Noel J.,Huang, Xinyan
supporting information, p. 1458 - 1461 (2014/03/21)
The NPY5 receptor binding and pharmacokinetic properties of a novel series of cis-1-oxo-heterocyclyl-4-amido-cyclohexane derivatives are described.