2-[(1-methylethyl)oxy]-5-(5-{3-[2-(methyloxy)ethyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,3,4-thiadiazol-2-yl)benzonitrile monohydrochloride

Base Information

Chemical Name:2-[(1-methylethyl)oxy]-5-(5-{3-[2-(methyloxy)ethyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,3,4-thiadiazol-2-yl)benzonitrile monohydrochloride
CAS No.:1258852-30-0
Molecular Formula:C₂₅H₂₈N₄O₂S*ClH
Molecular Weight:485.05
Hs Code.:

Synonyms:2-[(1-methylethyl)oxy]-5-(5-{3-[2-(methyloxy)ethyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,3,4-thiadiazol-2-yl)benzonitrile monohydrochloride

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Chemical Property of 2-[(1-methylethyl)oxy]-5-(5-{3-[2-(methyloxy)ethyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,3,4-thiadiazol-2-yl)benzonitrile monohydrochloride

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Technology Process of 2-[(1-methylethyl)oxy]-5-(5-{3-[2-(methyloxy)ethyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,3,4-thiadiazol-2-yl)benzonitrile monohydrochloride

There total 11 articles about 2-[(1-methylethyl)oxy]-5-(5-{3-[2-(methyloxy)ethyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,3,4-thiadiazol-2-yl)benzonitrile monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1258440-10-6
2-[(1-methylethyl)oxy]-5-[5-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3,4-thiadiazol-2-yl]benzonitrile mono-trifluoroacetate

: 6482-24-2
2-Bromoethyl methyl ether

: 1258852-30-0
2-[(1-methylethyl)oxy]-5-(5-{3-[2-(methyloxy)ethyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,3,4-thiadiazol-2-yl)benzonitrile monohydrochloride

Guidance literature:: 2-[(1-methylethyl)oxy]-5-[5-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)-1,3,4-thiadiazol-2-yl]benzonitrile mono-trifluoroacetate; 2-Bromoethyl methyl ether; With potassium carbonate; In acetone; at 90 ℃; for 0.333333h; Irradiation with microwave;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 611-20-1
salicylonitrile

: 1258852-30-0
2-[(1-methylethyl)oxy]-5-(5-{3-[2-(methyloxy)ethyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,3,4-thiadiazol-2-yl)benzonitrile monohydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: trifluorormethanesulfonic acid; N-iodo-succinimide / acetonitrile / 0 - 20 °C

2: potassium carbonate / acetonitrile / Reflux

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 90 °C / Inert atmosphere

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere

5: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.33 h / 120 °C / Irradiation with microwave

6: dichloromethane / 18 h / 20 °C

7: potassium carbonate / acetone / 0.33 h / 90 °C / Irradiation with microwave

With potassium phosphate; N-iodo-succinimide; trifluorormethanesulfonic acid; potassium acetate; sodium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 258273-31-3
3-cyano-4-isopropoxybenzoic acid

: 1258852-30-0
2-[(1-methylethyl)oxy]-5-(5-{3-[2-(methyloxy)ethyl]-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl}-1,3,4-thiadiazol-2-yl)benzonitrile monohydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 3 h / 90 °C

1.2: 35 °C / pH 10 / Cooling with ice

2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 - 70 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.33 h / 120 °C / Irradiation with microwave

4.1: dichloromethane / 18 h / 20 °C

5.1: potassium carbonate / acetone / 0.33 h / 90 °C / Irradiation with microwave

With potassium phosphate; tert.-butylnitrite; potassium carbonate; copper(ll) bromide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;