C₂₈H₂₆F₅NO₂

Base Information

Chemical Name:C₂₈H₂₆F₅NO₂
CAS No.:940932-62-7
Molecular Formula:C₂₈H₂₆F₅NO₂
Molecular Weight:503.512
Hs Code.:

C<sub>28</sub>H<sub>26</sub>F<sub>5</sub>NO<sub>2</sub>

Synonyms:C₂₈H₂₆F₅NO₂

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Chemical Property of C₂₈H₂₆F₅NO₂

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Technology Process of C₂₈H₂₆F₅NO₂

There total 10 articles about C₂₈H₂₆F₅NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 940932-56-9
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-(N-hydroxylamino)estr-9-ene

: 940932-62-7
C₂₈H₂₆F₅NO₂

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / Na₂B₄O₇; aq. HCl; 2-mercaptoethyl ether / FeSO₄(NH₄)2SO₄ / tetrahydrofuran; ethanol / 5 h / Heating

2: Et₃N / CH₂Cl₂

3: aq. TFA / CH₂Cl₂

With hydrogenchloride; borax; triethylamine; trifluoroacetic acid; FeSO₄(NH₄)2SO₄; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol070447d

Reference yield:

: 940932-55-8
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-nitroestr-9-ene

: 940932-62-7
C₂₈H₂₆F₅NO₂

Guidance literature:: Multi-step reaction with 4 steps

1: Zn; aq. NH₄Cl / tetrahydrofuran; ethanol / 0.5 h

2: 82 percent / Na₂B₄O₇; aq. HCl; 2-mercaptoethyl ether / FeSO₄(NH₄)2SO₄ / tetrahydrofuran; ethanol / 5 h / Heating

3: Et₃N / CH₂Cl₂

4: aq. TFA / CH₂Cl₂

With hydrogenchloride; borax; ammonium chloride; triethylamine; trifluoroacetic acid; zinc; FeSO₄(NH₄)2SO₄; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol070447d

Reference yield:

: 940932-53-6
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-5α-hydroxy-17-(N-hydroxyimino)estr-9-ene

: 940932-62-7
C₂₈H₂₆F₅NO₂

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-bromosuccinimide; aq. KHCO₃ / dioxane / 16 h / 20 °C

2.1: 10.3 g / NaBH₄ / dioxane; H₂O / 1 h

3.1: KOtBu / dimethylsulfoxide / 1 h / 20 °C

3.2: 81 percent / Pb(OAc)2 / dimethylsulfoxide / 0.33 h

4.1: Zn; aq. NH₄Cl / tetrahydrofuran; ethanol / 0.5 h

5.1: 82 percent / Na₂B₄O₇; aq. HCl; 2-mercaptoethyl ether / FeSO₄(NH₄)2SO₄ / tetrahydrofuran; ethanol / 5 h / Heating

6.1: Et₃N / CH₂Cl₂

7.1: aq. TFA / CH₂Cl₂

With hydrogenchloride; borax; sodium tetrahydroborate; N-Bromosuccinimide; potassium tert-butylate; ammonium chloride; potassium hydrogencarbonate; triethylamine; trifluoroacetic acid; zinc; FeSO₄(NH₄)2SO₄; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/ol070447d